{"id":"W2154816100","doi":"10.1073/pnas.1210633110","title":"PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS","year":2013,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":209,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"ZonMw; Canadian Institutes of Health Research; Terry Fox Foundation; European Commission","keywords":"Integrated stress response; Biology; Radioresistance; Unfolded protein response; Hypoxia (environmental); Glutathione; Cell biology; Cancer research; ATF4; Endoplasmic reticulum; Kinase; eIF2; Biochemistry; Cell culture; Chemistry; Translation (biology); Enzyme; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001309404,0.0002992735,0.0002531264,0.000202135,0.0001629202,0.0002242042,0.0001140477,0.0002017586,0.001244904],"category_scores_gemma":[0.00007945844,0.0001001005,0.0001939567,0.0001232229,0.0001527711,0.0001631212,0.0001611401,0.0003319526,0.000318564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001929843,"about_ca_system_score_gemma":0.0001895907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001946206,"about_ca_topic_score_gemma":0.0003334904,"domain_scores_codex":[0.9999462,0.000009045858,0.000005332341,0.00001009425,0.00001160929,0.0000176396],"domain_scores_gemma":[0.9999583,0.000003360832,0.00001135168,0.000007850914,0.000005379437,0.00001381309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002203943,0.0000269507,0.0001285037,0.00004049558,0.000005948171,0.00003420358,0.00000914342,0.00008943312,0.9965386,0.0001075486,0.00009462718,0.002704146],"study_design_scores_gemma":[0.00005420757,0.0005319115,0.006285425,0.000008256776,0.0000188332,0.0002840902,0.00003785641,0.0007267648,0.9868937,0.000168362,0.004985287,0.00000527028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911573,0.002558592,0.003236246,0.000366724,0.0001008907,0.00003043396,0.000482296,0.0002347061,0.001832822],"genre_scores_gemma":[0.994009,0.001202226,0.001500241,0.0001062339,0.00002203271,0.00002294949,0.0005628748,0.0000157784,0.002558683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001244904,"threshold_uncertainty_score":0.004164636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03018762012302785,"score_gpt":0.2598647920949937,"score_spread":0.2296771719719659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}