{"id":"W2154833452","doi":"10.7554/elife.06857","title":"Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells","year":2015,"lang":"en","type":"article","venue":"eLife","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":207,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"National Institutes of Health; Institut National Du Cancer; Centre National de la Recherche Scientifique; Ligue Contre le Cancer; Institut National de la Santé et de la Recherche Médicale; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Fondation ARC pour la Recherche sur le Cancer; Agence Nationale de la Recherche","keywords":"Microphthalmia-associated transcription factor; SOX10; Transcription factor; Chromatin; IRF4; Enhancer; Biology; Cell biology; Regulator; Chromatin immunoprecipitation; Chromatin remodeling; Genetics; CTCF; Promoter; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001563299,0.0001140341,0.0001082684,0.00002964069,0.00003364741,0.0000120281,0.0000581008,0.0001166162,0.00003880396],"category_scores_gemma":[0.00001615707,0.0001129292,0.0000271668,0.00003774377,0.00002461017,0.000005309376,0.00003579474,0.00004567896,0.00002078665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007276236,"about_ca_system_score_gemma":0.00006017405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000414622,"about_ca_topic_score_gemma":0.0001427788,"domain_scores_codex":[0.9991791,0.00004128916,0.0002205028,0.0002446555,0.0001690614,0.0001454251],"domain_scores_gemma":[0.9996279,0.000003012068,0.00006090244,0.0001818016,0.00004326944,0.00008307627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006456488,0.00002582849,0.003254885,0.0000164105,0.0000109582,7.403709e-7,0.0003845685,0.0002214039,0.9916232,0.000003817729,0.002774834,0.001618834],"study_design_scores_gemma":[0.002110296,0.0002406438,0.01149249,0.00003481414,0.00001385614,0.00001022598,0.0001601313,0.003923702,0.9677079,0.00004498453,0.01397912,0.0002818423],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975845,0.001148853,0.0005992327,0.0000602712,0.0001235727,0.0001256469,0.00001514505,0.00001378313,0.0003290358],"genre_scores_gemma":[0.9974355,0.0002063581,0.00134121,0.0001821846,0.0001112152,0.000006887847,0.0001009345,0.00001952543,0.00059623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02391526,"threshold_uncertainty_score":0.4605118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02123392735777721,"score_gpt":0.2411676000175439,"score_spread":0.2199336726597667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}