{"id":"W2154833452","doi":"10.7554/elife.06857","title":"Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells","year":2015,"lang":"en","type":"article","venue":"eLife","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":207,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"National Institutes of Health; Institut National Du Cancer; Centre National de la Recherche Scientifique; Ligue Contre le Cancer; Institut National de la Santé et de la Recherche Médicale; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Fondation ARC pour la Recherche sur le Cancer; Agence Nationale de la Recherche","keywords":"Microphthalmia-associated transcription factor; SOX10; Transcription factor; Chromatin; IRF4; Enhancer; Biology; Cell biology; Regulator; Chromatin immunoprecipitation; Chromatin remodeling; Genetics; CTCF; Promoter; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007212898,0.0001519464,0.0001445826,0.0004186722,0.0001693076,0.00027723,0.0001153382,0.0002677929,0.0008160939],"category_scores_gemma":[0.0001041174,0.0001839837,0.0001271853,0.0001856335,0.000174935,0.0001509956,0.0002184632,0.000206742,0.0003848605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002934766,"about_ca_system_score_gemma":0.00009895663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001498575,"about_ca_topic_score_gemma":0.003293482,"domain_scores_codex":[0.9999123,0.000007543468,0.000002875201,0.00002726021,0.00002243055,0.00002770574],"domain_scores_gemma":[0.999944,0.000005308608,0.00001698095,0.000005373177,0.000007238727,0.0000211814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004720634,0.000002581284,0.001832373,0.000009271513,0.000002473284,0.00002945351,0.00002580576,0.00003672148,0.9970233,0.00007563614,0.00003048123,0.000884616],"study_design_scores_gemma":[0.00001981834,0.0001152329,0.3433904,0.00001343715,0.00001792519,0.001101576,0.000178585,0.002192104,0.6467507,0.0003418193,0.005864417,0.00001402257],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943446,0.001979757,0.002201751,0.00003798642,0.000006198813,0.000008556865,0.0002805556,0.0000587952,0.00108178],"genre_scores_gemma":[0.9967384,0.0002655465,0.001333181,0.00003103901,0.000002845439,0.000007617375,0.0004488135,0.00001440219,0.00115828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001498575,"threshold_uncertainty_score":0.002979696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02123392735777721,"score_gpt":0.2411676000175439,"score_spread":0.2199336726597667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}