{"id":"W2154852038","doi":"10.1083/jcb.201108088","title":"The synaptic vesicle SNARE neuronal Synaptobrevin promotes endolysosomal degradation and prevents neurodegeneration","year":2012,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Eye Institute","keywords":"Biology; Cell biology; Neurodegeneration; Endosome; Synaptic vesicle; Synaptobrevin; Neuron; SNAP25; Vesicle; Neuroscience; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001190215,0.0002123635,0.0002845847,0.0001935432,0.0001064299,0.000266131,0.0001920485,0.0002163816,0.0006033867],"category_scores_gemma":[0.0001522811,0.00009756549,0.000127888,0.0001047274,0.0002137522,0.000163869,0.0001684398,0.0003164915,0.0002269988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002177185,"about_ca_system_score_gemma":0.0002230715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005439669,"about_ca_topic_score_gemma":0.001289132,"domain_scores_codex":[0.9999216,0.00001279167,0.000009802935,0.00001343266,0.0000234566,0.00001896178],"domain_scores_gemma":[0.9999028,0.00001237981,0.00002115542,0.00001602842,0.0000132805,0.00003438267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001978159,0.00004681508,0.0002076407,0.00002925634,0.00001111436,0.00003487505,0.00000763546,0.00005723128,0.9974378,0.0000863968,0.00005851545,0.001824801],"study_design_scores_gemma":[0.00002961591,0.0003730947,0.004461098,0.000008871606,0.00002038581,0.0001987602,0.00001610032,0.0005419728,0.99306,0.00006770936,0.001219484,0.000002945253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974204,0.001033619,0.0007227232,0.00004957693,0.0000141272,0.00000633428,0.00008633665,0.00006841552,0.0005983985],"genre_scores_gemma":[0.9966814,0.0007401026,0.0007358583,0.0000228424,0.000005606537,0.00001043473,0.0002404441,0.00001974913,0.00154358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006033867,"threshold_uncertainty_score":0.002018511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01012803146353291,"score_gpt":0.2194674995037776,"score_spread":0.2093394680402447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}