{"id":"W2154861812","doi":"10.1016/j.regpep.2004.05.025","title":"Pituitary adenylate cyclase-activating polypeptide inhibits caspase-3 activity but does not protect cerebellar granule neurons against β-amyloid (25–35)-induced apoptosis","year":2004,"lang":"en","type":"article","venue":"Regulatory Peptides","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Institut National de la Santé et de la Recherche Médicale","keywords":"Granule cell; Granule (geology); Neuroprotection; Caspase 3; Apoptosis; Neurotoxicity; Neurite; Caspase; Cell biology; Pituitary adenylate cyclase-activating peptide; Programmed cell death; Cerebellum; Chemistry; Adenylate kinase; Biology; Internal medicine; Endocrinology; Biochemistry; Neuropeptide; Pharmacology; Toxicity; Central nervous system; Vasoactive intestinal peptide; In vitro; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000277486,0.0006559613,0.0007749079,0.0004624025,0.0003613404,0.0005966417,0.000518302,0.0006615758,0.002689544],"category_scores_gemma":[0.0004890118,0.0003313175,0.0005665899,0.0003720525,0.001079968,0.0007286296,0.0003191351,0.001905854,0.0006447561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008072982,"about_ca_system_score_gemma":0.001390118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003984001,"about_ca_topic_score_gemma":0.005016126,"domain_scores_codex":[0.9996712,0.00002978545,0.00002919113,0.00005285982,0.00006379378,0.0001532476],"domain_scores_gemma":[0.9995427,0.0001348803,0.00006669605,0.00007897129,0.00003002267,0.000146717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002101943,0.0001845823,0.000258054,0.0001281256,0.00003827956,0.0002789104,0.00006165498,0.0001283319,0.9939898,0.0002188506,0.0002397781,0.00237164],"study_design_scores_gemma":[0.0004654843,0.001876789,0.007102623,0.0000259459,0.00007892594,0.000670983,0.000204856,0.000892492,0.9850674,0.0003401852,0.003248817,0.00002553565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917447,0.002987531,0.001049884,0.0004713972,0.00018623,0.00004554823,0.0005645506,0.0001466407,0.002803446],"genre_scores_gemma":[0.9926736,0.001799464,0.001160739,0.0001355086,0.0000455377,0.00005736218,0.00103885,0.00003373335,0.003055252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003984001,"threshold_uncertainty_score":0.008997381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03326288636714224,"score_gpt":0.2472699516171692,"score_spread":0.2140070652500269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}