{"id":"W2154861812","doi":"10.1016/j.regpep.2004.05.025","title":"Pituitary adenylate cyclase-activating polypeptide inhibits caspase-3 activity but does not protect cerebellar granule neurons against β-amyloid (25–35)-induced apoptosis","year":2004,"lang":"en","type":"article","venue":"Regulatory Peptides","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Institut National de la Santé et de la Recherche Médicale","keywords":"Granule cell; Granule (geology); Neuroprotection; Caspase 3; Apoptosis; Neurotoxicity; Neurite; Caspase; Cell biology; Pituitary adenylate cyclase-activating peptide; Programmed cell death; Cerebellum; Chemistry; Adenylate kinase; Biology; Internal medicine; Endocrinology; Biochemistry; Neuropeptide; Pharmacology; Toxicity; Central nervous system; Vasoactive intestinal peptide; In vitro; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000254506,0.0009101517,0.0008429872,0.0003262916,0.001209989,0.0002053152,0.0007647457,0.0002935366,0.00005165393],"category_scores_gemma":[0.0005858228,0.0007701337,0.0004704417,0.0006287438,0.0005505619,0.001048509,0.0005148001,0.001110476,0.0002344204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002751703,"about_ca_system_score_gemma":0.0002558941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004176121,"about_ca_topic_score_gemma":0.00007069116,"domain_scores_codex":[0.9946582,0.0004883442,0.0007502171,0.001903651,0.0007702691,0.001429351],"domain_scores_gemma":[0.9973335,0.000372943,0.0005451866,0.001152657,0.0000889912,0.0005066837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002084429,0.0003120906,0.0001106434,0.0001142878,0.00002455975,0.0001149237,0.0001748683,0.0006872409,0.9927345,0.0004677534,0.00005808887,0.004992632],"study_design_scores_gemma":[0.001100625,0.0005167631,0.009020826,0.0002194796,0.00003097904,0.00006761008,0.0001032559,0.0001028975,0.9868199,0.0005253981,0.0005650424,0.0009272347],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995905,0.0000237641,0.00001770692,0.0005642729,0.0004492595,0.00112825,0.0001615298,0.0006711269,0.001079029],"genre_scores_gemma":[0.9961523,0.00006539498,0.000293982,0.002012511,0.0005588304,0.000116481,0.000008075443,0.0002148605,0.0005775099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008910182,"threshold_uncertainty_score":0.9994749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03326288636714224,"score_gpt":0.2472699516171692,"score_spread":0.2140070652500269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}