{"id":"W2154864077","doi":"","title":"A randomized phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer.","year":2002,"lang":"en","type":"article","venue":"PubMed","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Prostate cancer; Medicine; Chemotherapy; Cancer; Protein kinase C; Randomization; Cancer research; Apoptosis; Oncology; Internal medicine; Kinase; Randomized controlled trial; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001569983,0.001762464,0.002412214,0.0005142375,0.0004004347,0.0008364884,0.0009030036,0.001575077,0.003979355],"category_scores_gemma":[0.001691505,0.0007800441,0.001099729,0.0004986773,0.001717479,0.0009451497,0.0003657066,0.002765536,0.0006533419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001154927,"about_ca_system_score_gemma":0.002342654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009167442,"about_ca_topic_score_gemma":0.001725343,"domain_scores_codex":[0.9992112,0.0004059375,0.00003506557,0.0001379202,0.00007118302,0.0001386928],"domain_scores_gemma":[0.9985893,0.0002921679,0.0003377745,0.0001182558,0.00005887694,0.0006035395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9242291,0.02579514,0.00265462,0.0002199697,0.0003934753,0.00009422528,0.0001520673,0.001494593,0.01688618,0.000281389,0.0009703481,0.02682874],"study_design_scores_gemma":[0.6930768,0.3004014,0.002765883,0.00001224263,0.000201254,0.00007145463,0.00003538627,0.0007877437,0.001435493,0.0001667896,0.001027271,0.00001823156],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918887,0.0008349381,0.000670029,0.000374816,0.0001618723,0.004353093,0.0005398787,0.00007834595,0.001098353],"genre_scores_gemma":[0.9886971,0.0006390642,0.002135849,0.0007616283,0.0002048069,0.005092216,0.0008563454,0.0000224447,0.001590489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003979355,"threshold_uncertainty_score":0.01331228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01011050225712903,"score_gpt":0.2251837435912747,"score_spread":0.2150732413341457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}