{"id":"W2154867920","doi":"10.1016/j.bmcl.2005.08.001","title":"Synthesis and SAR of highly selective MMP-13 inhibitors","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Sulfonamide; Matrix metalloproteinase; Aggrecanase; Selectivity; Stereochemistry; Chemical synthesis; Structure–activity relationship; Enzyme inhibitor; Combinatorial chemistry; Carboxamide; Pharmacology; Biochemistry; Enzyme; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002657624,0.0005184169,0.0003756056,0.0002032037,0.0002010028,0.0003484873,0.0004148321,0.0002443607,0.001580571],"category_scores_gemma":[0.0001805325,0.0002705898,0.0002221771,0.0002214643,0.0001633067,0.0002752765,0.0002339018,0.0007435009,0.0006796162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004783057,"about_ca_system_score_gemma":0.0004850536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005627131,"about_ca_topic_score_gemma":0.001579565,"domain_scores_codex":[0.9998931,0.00001347414,0.000009527964,0.00001104684,0.0000309422,0.0000418535],"domain_scores_gemma":[0.9999489,0.000007751814,0.00001122973,0.000005004614,0.000009199242,0.00001802203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009578335,0.0004458386,0.0002635718,0.000449457,0.00005949731,0.0006942097,0.0001374644,0.007092594,0.9175253,0.004283071,0.004463759,0.06362747],"study_design_scores_gemma":[0.0004281233,0.001548565,0.0008337083,0.00003213884,0.00006506834,0.0007316716,0.00002961401,0.004001649,0.9515463,0.0006344896,0.04012158,0.00002711609],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.872394,0.02790052,0.06362893,0.002020346,0.0004447967,0.00104287,0.003650655,0.0007435366,0.02817435],"genre_scores_gemma":[0.9291098,0.02644406,0.02554915,0.0004675734,0.0000879644,0.0003190995,0.003016849,0.00005764496,0.01494792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001580571,"threshold_uncertainty_score":0.005287528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004667706794928407,"score_gpt":0.198694301433209,"score_spread":0.1940265946382806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}