{"id":"W2154876324","doi":"10.1186/s12964-015-0097-7","title":"Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells","year":2015,"lang":"en","type":"article","venue":"Cell Communication and Signaling","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Société Francophone du Diabète; Fondation pour la Recherche Médicale; Canadian Diabetes Association; European Foundation for the Study of Diabetes; AstraZeneca; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Microvesicles; microRNA; Exosome; Cell biology; Biology; Cell culture; Pancreatic islets; Cell type; Cell; Cancer research; Islet; Endocrinology; Insulin; Biochemistry; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002792956,0.0004193418,0.0002528891,0.000178569,0.0001589199,0.0004406699,0.0002920924,0.0004373087,0.001855679],"category_scores_gemma":[0.0002783859,0.0001545009,0.0003864145,0.0001010108,0.0002556213,0.0003307166,0.000557664,0.0008450252,0.0005021048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002604736,"about_ca_system_score_gemma":0.0001378943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007619725,"about_ca_topic_score_gemma":0.00008717843,"domain_scores_codex":[0.9996755,0.00004240366,0.00002565411,0.00009755758,0.00009824381,0.00006071669],"domain_scores_gemma":[0.9997428,0.00006627864,0.00008063752,0.00005147137,0.00002185981,0.00003693193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009858429,0.00003454251,0.0003586331,0.00004811282,0.000007164151,0.00005773538,0.00002801152,0.00002148607,0.9975248,0.0001757269,0.00002785863,0.001617325],"study_design_scores_gemma":[0.0000114302,0.0003128942,0.002204848,0.00001100417,0.00001702052,0.0001825033,0.00003850113,0.0004882927,0.9945691,0.00005664083,0.002104287,0.000003548861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888636,0.0006982992,0.008291938,0.0000943994,0.0001146131,0.00008903672,0.0002418416,0.0001101778,0.00149615],"genre_scores_gemma":[0.9906082,0.0004468486,0.005796663,0.00005471304,0.00002075259,0.00009029787,0.0003866459,0.00004611986,0.002549778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001855679,"threshold_uncertainty_score":0.006207824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02542433823817173,"score_gpt":0.2479298383242643,"score_spread":0.2225055000860926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}