{"id":"W2154886355","doi":"10.1126/science.1066901","title":"Adult-Onset Primary Open-Angle Glaucoma Caused by Mutations in Optineurin","year":2002,"lang":"en","type":"article","venue":"Science","topic":"Glaucoma and retinal disorders","field":"Medicine","cited_by":1102,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Clair College; Toronto Western Hospital","funders":"National Eye Institute","keywords":"Optineurin; Trabecular meshwork; Biology; Glaucoma; Genetics; Missense mutation; Myocilin; Mutation; Huntingtin; Gene; Open angle glaucoma; Cell biology; Neuroscience; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001628143,0.0003504583,0.0002096027,0.0003991027,0.0002165872,0.0001546004,0.0000968618,0.0002056404,0.001151656],"category_scores_gemma":[0.0004906441,0.00008523394,0.0001216787,0.0002395238,0.0002911568,0.0001380542,0.0002111889,0.0001258122,0.0001848091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001222602,"about_ca_system_score_gemma":0.0001042732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000491288,"about_ca_topic_score_gemma":0.0006037298,"domain_scores_codex":[0.9998934,0.00002615895,0.00001394418,0.00002471089,0.00002560297,0.00001615438],"domain_scores_gemma":[0.9998549,0.00003021507,0.00007031684,0.000008865943,0.0000132899,0.00002240619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001447288,0.0001635577,0.6734465,0.0002639328,0.0002137956,0.03578431,0.0006824266,0.0002018287,0.2175943,0.0009192363,0.002196897,0.06708603],"study_design_scores_gemma":[0.00008758346,0.0004684086,0.8766052,0.00006467811,0.0001688539,0.090392,0.0002100777,0.0005564319,0.02233643,0.0005685373,0.008531575,0.00001021609],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959395,0.002399751,0.0004897258,0.00009336802,0.00001651889,0.000007458462,0.0001129735,0.0000209294,0.000919927],"genre_scores_gemma":[0.9982269,0.0009055998,0.0003047622,0.00005489135,0.00002137014,0.000005033188,0.00009483217,0.000002982517,0.0003835706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001151656,"threshold_uncertainty_score":0.003852665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01570797903914486,"score_gpt":0.2735618540722306,"score_spread":0.2578538750330858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}