{"id":"W2154886355","doi":"10.1126/science.1066901","title":"Adult-Onset Primary Open-Angle Glaucoma Caused by Mutations in Optineurin","year":2002,"lang":"en","type":"article","venue":"Science","topic":"Glaucoma and retinal disorders","field":"Medicine","cited_by":1102,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Clair College; Toronto Western Hospital","funders":"National Eye Institute","keywords":"Optineurin; Trabecular meshwork; Biology; Glaucoma; Genetics; Missense mutation; Myocilin; Mutation; Huntingtin; Gene; Open angle glaucoma; Cell biology; Neuroscience; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002097142,0.00008826155,0.0001415775,0.0001431577,0.0001537424,0.00005620202,0.0003732498,0.00003075187,0.0002349165],"category_scores_gemma":[0.0002135393,0.0000730494,0.0000248665,0.0009895847,0.0004307226,0.0002354035,0.0001134312,0.000129836,0.0001700284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000653193,"about_ca_system_score_gemma":0.00009520026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001035424,"about_ca_topic_score_gemma":0.00007725096,"domain_scores_codex":[0.9988662,0.00002247293,0.0001724611,0.0003058749,0.0003260412,0.0003069538],"domain_scores_gemma":[0.9994563,0.00003286247,0.00003881448,0.000250949,0.000076476,0.0001445343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00004702148,0.0009923762,0.889848,0.00005129045,0.000006195317,0.0001873712,0.001552366,0.000001451333,0.07652852,0.000333452,0.0245842,0.005867749],"study_design_scores_gemma":[0.001385016,0.0002009381,0.9900032,0.00006558506,0.00001061266,0.00006462689,0.000332236,0.001276305,0.002443548,0.0001470675,0.003933903,0.0001369261],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748614,0.0002410945,0.00001618609,0.003750646,0.00009038278,0.0003401769,0.000006379405,0.00002965722,0.02066412],"genre_scores_gemma":[0.9941927,0.00004148344,0.0007465483,0.001447524,0.00001019533,0.00002326347,0.00001226918,0.000008057513,0.003518012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1001552,"threshold_uncertainty_score":0.2978868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01570797903914486,"score_gpt":0.2735618540722306,"score_spread":0.2578538750330858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}