{"id":"W2154913350","doi":"10.1002/mds.22218","title":"A randomized, double‐blind, placebo‐controlled, delayed start study to assess rasagiline as a disease modifying therapy in Parkinson's disease (the ADAGIO study): Rationale, design, and baseline characteristics","year":2008,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":166,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital","funders":"","keywords":"Rasagiline; Medicine; Placebo; Disease; Clinical trial; Confounding; Parkinson's disease; Clinical study design; Randomized controlled trial; Physical therapy; Internal medicine; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005978479,0.002332289,0.00394965,0.0007087465,0.0009346286,0.001185345,0.001031961,0.00255071,0.004083436],"category_scores_gemma":[0.004112081,0.001071806,0.001340114,0.0007234442,0.001861924,0.001300497,0.0005822357,0.002456707,0.0009069234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005196633,"about_ca_system_score_gemma":0.001834504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004238902,"about_ca_topic_score_gemma":0.001048503,"domain_scores_codex":[0.9973255,0.001751173,0.0001803183,0.0002795431,0.0002695674,0.0001938933],"domain_scores_gemma":[0.9977764,0.0007563696,0.0004818125,0.0002484601,0.0001894075,0.0005475179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9761246,0.008305188,0.001359711,0.0007897355,0.0005072678,0.00005416344,0.00007325393,0.0002168218,0.003721309,0.0004584918,0.000546251,0.007843299],"study_design_scores_gemma":[0.9225333,0.0738125,0.001385988,0.00002627938,0.0003195711,0.00003421377,0.00001197442,0.0001634561,0.000392104,0.0002323366,0.001071352,0.00001691166],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.8988011,0.01163764,0.003556496,0.001603456,0.001317481,0.0768026,0.002766183,0.0001807642,0.003334302],"genre_scores_gemma":[0.841231,0.006465966,0.01584436,0.002925704,0.001963062,0.1230461,0.002026743,0.0000524096,0.006444634],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.005978479,"threshold_uncertainty_score":0.03161758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05812267043023001,"score_gpt":0.3094575916417789,"score_spread":0.2513349212115489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}