{"id":"W2154921342","doi":"10.1152/ajprenal.00243.2011","title":"Tolvaptan inhibits ERK-dependent cell proliferation, Cl<sup>−</sup>secretion, and in vitro cyst growth of human ADPKD cells stimulated by vasopressin","year":2011,"lang":"en","type":"article","venue":"American Journal of Physiology-Renal Physiology","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Tolvaptan; Vasopressin; Endocrinology; Internal medicine; Cell growth; Arginine vasopressin receptor 2; Autosomal dominant polycystic kidney disease; Secretion; Intracellular; MAPK/ERK pathway; Biology; Chemistry; Cell biology; Medicine; Signal transduction; Kidney; Receptor; Antagonist; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006652187,0.0002653935,0.0002617582,0.000101896,0.0001274224,0.0003005287,0.0001592643,0.0001792483,0.0007832902],"category_scores_gemma":[0.000151087,0.0001127445,0.0001846931,0.00009495273,0.0001689122,0.0001291784,0.0001253125,0.0004779858,0.0002297523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002534206,"about_ca_system_score_gemma":0.0002121111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006211613,"about_ca_topic_score_gemma":0.001133681,"domain_scores_codex":[0.9999194,0.00001658493,0.00001230104,0.000009091001,0.00002222484,0.00002045561],"domain_scores_gemma":[0.9999384,0.00001868368,0.00001515977,0.000007221332,0.000005850384,0.0000147973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003629553,0.00005868002,0.0002244417,0.00006679463,0.000006564037,0.00007022798,0.00002086285,0.0001629203,0.9967409,0.00005038246,0.00008279472,0.002152552],"study_design_scores_gemma":[0.00006275934,0.0007638265,0.005683165,0.000005507566,0.0000135894,0.000463083,0.00003965973,0.001043265,0.9897311,0.00003865421,0.002149578,0.000005814708],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971848,0.0009334864,0.0004576637,0.00005408482,0.000015269,0.00001219451,0.0002996038,0.00002970706,0.001013338],"genre_scores_gemma":[0.9957513,0.0009672799,0.001043069,0.00004781868,0.000008534058,0.00003612908,0.0007967987,0.000009854965,0.001339157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007832902,"threshold_uncertainty_score":0.002620399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00600091080539159,"score_gpt":0.214693843261486,"score_spread":0.2086929324560944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}