{"id":"W2154921342","doi":"10.1152/ajprenal.00243.2011","title":"Tolvaptan inhibits ERK-dependent cell proliferation, Cl<sup>−</sup>secretion, and in vitro cyst growth of human ADPKD cells stimulated by vasopressin","year":2011,"lang":"en","type":"article","venue":"American Journal of Physiology-Renal Physiology","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Tolvaptan; Vasopressin; Endocrinology; Internal medicine; Cell growth; Arginine vasopressin receptor 2; Autosomal dominant polycystic kidney disease; Secretion; Intracellular; MAPK/ERK pathway; Biology; Chemistry; Cell biology; Medicine; Signal transduction; Kidney; Receptor; Antagonist; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001946074,0.0003394567,0.0007521381,0.000167546,0.0000826424,0.000008102953,0.0003575321,0.0001815161,0.00005515624],"category_scores_gemma":[0.00005599797,0.0002957308,0.0001736723,0.0001892278,0.0008067121,0.00001908683,0.000149168,0.0002726842,0.000003272146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001942336,"about_ca_system_score_gemma":0.0001724655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001007088,"about_ca_topic_score_gemma":0.000004174697,"domain_scores_codex":[0.9976248,0.0004582278,0.0008433089,0.0004833624,0.0001701661,0.0004201165],"domain_scores_gemma":[0.9981483,0.00003713875,0.0008764003,0.0003005051,0.0003826733,0.0002549441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001839477,0.0005144647,0.0007056381,0.00004810572,0.0001201285,0.0000046939,0.0002917267,0.0003029594,0.9952452,0.000006013821,0.0007977877,0.0001237785],"study_design_scores_gemma":[0.001831787,0.002912337,0.01657773,0.00003360609,0.00008118382,0.00003081508,0.0003367361,0.0001171011,0.9769918,0.0007436564,0.00004802724,0.0002951626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988462,0.0005752403,0.0001000578,0.00003242543,0.00006184641,0.0001911268,0.0001144632,0.000006533843,0.00007207187],"genre_scores_gemma":[0.9985452,0.0001785286,0.0005072211,0.0003073943,0.0001806295,0.00001227472,0.0002003305,0.00003364985,0.00003471603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01825337,"threshold_uncertainty_score":0.9999495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00600091080539159,"score_gpt":0.214693843261486,"score_spread":0.2086929324560944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}