{"id":"W2154937731","doi":"10.1152/ajpheart.00036.2004","title":"In vivo TNF-α inhibition ameliorates cardiac mitochondrial dysfunction, oxidative stress, and apoptosis in experimental heart failure","year":2004,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":159,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Oxidative stress; TUNEL assay; Heart failure; Internal medicine; Ejection fraction; Endocrinology; Medicine; Etanercept; Apoptosis; Cardiac function curve; Tumor necrosis factor alpha; Biology; Biochemistry; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003812042,0.0005331856,0.000773368,0.0003046481,0.0001956193,0.0002655193,0.0002591817,0.0003281973,0.0009493907],"category_scores_gemma":[0.0002407011,0.0001991797,0.0002818615,0.0001236916,0.0003815628,0.0003689051,0.0001608529,0.0009504474,0.0001974896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002487017,"about_ca_system_score_gemma":0.0002440119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003052558,"about_ca_topic_score_gemma":0.0006744897,"domain_scores_codex":[0.999823,0.00004422256,0.00002516235,0.00002855559,0.00003082796,0.0000482027],"domain_scores_gemma":[0.9996989,0.00002613519,0.000105822,0.00003242066,0.00001912299,0.0001176622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0102867,0.002424693,0.0009626116,0.000125644,0.00004679937,0.0001472166,0.00004762329,0.0002738551,0.9770437,0.0000821295,0.0001483981,0.008410561],"study_design_scores_gemma":[0.00469834,0.1400599,0.03466243,0.00009299294,0.0002953019,0.001576686,0.0002341866,0.004015309,0.8096183,0.0002458072,0.004466254,0.00003450077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980353,0.0008623973,0.0005982471,0.00007627872,0.00005469501,0.0000374205,0.00007311759,0.00003337895,0.0002291988],"genre_scores_gemma":[0.9962056,0.001099147,0.001104249,0.00007364441,0.00006483575,0.00008405042,0.0002859193,0.0000104924,0.001072028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009493907,"threshold_uncertainty_score":0.003175974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007753626036912583,"score_gpt":0.2455804665046986,"score_spread":0.2378268404677861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}