{"id":"W2154959108","doi":"10.1093/hmg/ddm383","title":"Polycystin-2 is regulated by endoplasmic reticulum-associated degradation","year":2008,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Endoplasmic reticulum; Biology; Cell biology; Degradation (telecommunications)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008535018,0.0003492907,0.0002389358,0.00006820302,0.0003096751,0.00003329331,0.0003335602,0.0002993834,0.0001078839],"category_scores_gemma":[0.00008626048,0.0003919658,0.0001919207,0.00018071,0.0002246901,0.000003111109,0.0001307162,0.0001191271,0.00004886118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002500671,"about_ca_system_score_gemma":0.0001403127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002695858,"about_ca_topic_score_gemma":0.00000731439,"domain_scores_codex":[0.9979588,0.0001313351,0.0003964806,0.0006397237,0.000378638,0.0004950559],"domain_scores_gemma":[0.9986699,0.000006224707,0.0001727105,0.0006842247,0.0001734671,0.0002934235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002504136,0.00015142,0.002979848,0.000008004301,0.0001090556,0.00002927404,0.00004802148,0.00004107509,0.9468492,0.00001310337,0.04964984,0.00009609364],"study_design_scores_gemma":[0.001244923,0.000405622,0.01874638,0.00001693909,0.00009642547,0.00007090009,0.00002752237,0.0001339627,0.9615701,0.0001521787,0.01699689,0.0005381783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929942,0.003463483,0.001458979,0.00009728618,0.0001024061,0.0003020803,0.0001196946,0.00005440364,0.001407495],"genre_scores_gemma":[0.991949,0.0004008904,0.0006662823,0.001163623,0.00007366428,0.00002726961,0.001645704,0.00008396312,0.003989568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03265295,"threshold_uncertainty_score":0.9998533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00980323148938362,"score_gpt":0.227104180070942,"score_spread":0.2173009485815584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}