{"id":"W2154990516","doi":"10.1124/jpet.106.102905","title":"The Dopamine Stabilizers (S)-(-)-(3-Methanesulfonyl-phenyl)-1-propyl-piperidine [(-)-OSU6162] and 4-(3-Methanesulfonylphenyl)-1-propyl-piperidine (ACR16) Show High in Vivo D2 Receptor Occupancy, Antipsychotic-Like Efficacy, and Low Potential for Motor Side Effects in the Rat","year":2006,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":77,"is_retracted":false,"has_abstract":false,"ca_institutions":"Schizophrenia Society of Ontario","funders":"Centre for Addiction and Mental Health; Eli Lilly and Company","keywords":"Neurochemical; Dopamine; Chemistry; Piperidine; Pharmacology; Catalepsy; Antipsychotic; Striatum; Nucleus accumbens; Dopamine receptor D2; Haloperidol; In vivo; Internal medicine; Stereochemistry; Medicine; Biology; Psychiatry; Schizophrenia (object-oriented programming)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001822088,0.0004514916,0.0004239874,0.0003210801,0.0001944551,0.0001811622,0.0002820758,0.0002612304,0.001831719],"category_scores_gemma":[0.000218484,0.0002033655,0.0002363698,0.0001651501,0.0002543506,0.0002281932,0.0001636185,0.0005948319,0.0005526922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001957357,"about_ca_system_score_gemma":0.0003049387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001065632,"about_ca_topic_score_gemma":0.002823515,"domain_scores_codex":[0.9998636,0.00002724761,0.00001285975,0.00001905385,0.00003645368,0.00004070038],"domain_scores_gemma":[0.9997388,0.00002358271,0.0001117482,0.00003142171,0.00002167793,0.00007276778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001167271,0.0001192828,0.0003121429,0.00004836991,0.00001931805,0.00004750144,0.00002058505,0.00007401285,0.9928953,0.0001126951,0.0001104852,0.005072966],"study_design_scores_gemma":[0.0002596652,0.008897981,0.006414078,0.000008928091,0.00004473354,0.0004362177,0.0000380753,0.0004873757,0.9816151,0.0000545977,0.00172694,0.00001634879],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967917,0.0007886195,0.0006891701,0.00005535286,0.00001765966,0.00003651371,0.000225773,0.0000722527,0.001322896],"genre_scores_gemma":[0.9951305,0.0008830827,0.001611832,0.00003365588,0.00001498023,0.00003598594,0.0004840879,0.00001887391,0.001786976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001831719,"threshold_uncertainty_score":0.006127656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01993556775535995,"score_gpt":0.3167431748712044,"score_spread":0.2968076071158445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}