{"id":"W2155018177","doi":"10.1093/toxsci/kfs177","title":"Subchronic Oral Exposure to Benzo(a)pyrene Leads to Distinct Transcriptomic Changes in the Lungs That Are Related to Carcinogenesis","year":2012,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"Health Canada; Cancer Research UK","keywords":"Benzo(a)pyrene; Carcinogenesis; Carcinogen; Transcriptome; Biology; DNA damage; Mutant; Gene; Molecular biology; Gene expression; Transgene; DNA adduct; Cancer research; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000747634,0.0002541043,0.000261265,0.0003896999,0.0001364335,0.0002005694,0.00008501144,0.0002444371,0.001178636],"category_scores_gemma":[0.00009059016,0.0001552976,0.0002563689,0.0001825575,0.0002365516,0.0001354102,0.0001704357,0.0004227113,0.0002405575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001222192,"about_ca_system_score_gemma":0.0001058519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006638229,"about_ca_topic_score_gemma":0.001135597,"domain_scores_codex":[0.9998978,0.000009711022,0.000005858029,0.00003040255,0.00002729936,0.00002891745],"domain_scores_gemma":[0.9998939,0.00001903884,0.00003149499,0.00001196257,0.00001703091,0.00002655414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004282126,0.000005915742,0.0004110182,0.000006633453,0.000002223493,0.00001649223,0.00001007622,0.000007233506,0.9992466,0.000005271967,0.000003866776,0.00024183],"study_design_scores_gemma":[0.000005411892,0.00069961,0.1337361,0.000005151069,0.00002986276,0.0002388813,0.0001285399,0.000202465,0.8643255,0.0000457029,0.0005759419,0.000006794277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964032,0.0007615925,0.001428087,0.00003139887,0.000008383407,0.00002024663,0.000655339,0.00003734345,0.0006544124],"genre_scores_gemma":[0.9946945,0.0006505401,0.0009327515,0.00004349694,0.000005966293,0.00005240711,0.0008119709,0.0000137762,0.002794593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001178636,"threshold_uncertainty_score":0.003942907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0455016297572049,"score_gpt":0.3110273649683976,"score_spread":0.2655257352111927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}