{"id":"W2155041167","doi":"10.1158/1078-0432.ccr-12-2459","title":"Topotecan and Doxorubicin Combination to Treat Recurrent Ovarian Cancer: The Influence of Drug Exposure Time and Delivery Systems to Achieve Optimum Therapeutic Activity","year":2013,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency; Centre for Drug Research and Development","funders":"University of British Columbia; Canadian Institutes of Health Research; British Columbia Innovation Council","keywords":"Topotecan; Pharmacology; Medicine; Doxorubicin; Ovarian cancer; Pharmacokinetics; Combination therapy; Drug; Paclitaxel; Chemotherapy; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001192888,0.0001382921,0.0002469634,0.00006061365,0.0001472561,0.0000764413,0.0002675403,0.0001289668,0.00002780038],"category_scores_gemma":[0.00006218935,0.0001023778,0.00004767242,0.0001914809,0.0001954851,0.00001064626,0.0002883193,0.0002748384,0.00000635153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005806491,"about_ca_system_score_gemma":0.000200207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005148984,"about_ca_topic_score_gemma":0.0005131654,"domain_scores_codex":[0.9982216,0.0004189256,0.0002847202,0.0004569702,0.0002976348,0.0003201576],"domain_scores_gemma":[0.9987116,0.0001689099,0.00007463594,0.0004007214,0.000413527,0.0002305379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009777788,0.0001250476,0.001417554,0.00006860137,0.00008718072,6.107342e-7,0.0003249499,0.0005240329,0.7971113,0.0001689252,0.0007529539,0.1984411],"study_design_scores_gemma":[0.008927602,0.02245241,0.3506983,0.001073636,0.0002851104,0.00001732498,0.001303789,0.005428175,0.551035,0.002221737,0.05475971,0.001797264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907601,0.003286402,0.00006122688,0.00448727,0.0001476505,0.001147934,0.00004396317,0.000005708418,0.00005971915],"genre_scores_gemma":[0.9939963,0.004236659,0.00002619291,0.0004686589,0.000168294,0.0004223454,0.000004422549,0.00001928294,0.0006578359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3492807,"threshold_uncertainty_score":0.7783758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06097591290692741,"score_gpt":0.401842975573094,"score_spread":0.3408670626661666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}