{"id":"W2155041167","doi":"10.1158/1078-0432.ccr-12-2459","title":"Topotecan and Doxorubicin Combination to Treat Recurrent Ovarian Cancer: The Influence of Drug Exposure Time and Delivery Systems to Achieve Optimum Therapeutic Activity","year":2013,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency; Centre for Drug Research and Development","funders":"University of British Columbia; Canadian Institutes of Health Research; British Columbia Innovation Council","keywords":"Topotecan; Pharmacology; Medicine; Doxorubicin; Ovarian cancer; Pharmacokinetics; Combination therapy; Drug; Paclitaxel; Chemotherapy; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001914138,0.0003533412,0.0003344326,0.0001839071,0.00009802301,0.0004611135,0.0001822421,0.0002527621,0.0008035646],"category_scores_gemma":[0.0001862666,0.0001111252,0.0001533552,0.000162679,0.0001577586,0.0003777636,0.0001573137,0.0004013154,0.0001606397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005010174,"about_ca_system_score_gemma":0.0003404055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008194189,"about_ca_topic_score_gemma":0.001987193,"domain_scores_codex":[0.9998829,0.0000201335,0.0000108211,0.00002550597,0.00003594624,0.00002453395],"domain_scores_gemma":[0.9999397,0.00001480195,0.00002187897,0.000004813488,0.000006469108,0.0000123003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007941138,0.0001877889,0.0003028331,0.00009546821,0.00001601048,0.00005123992,0.00001754288,0.0006795305,0.9874702,0.00009353895,0.00008284192,0.01020891],"study_design_scores_gemma":[0.0001441213,0.002819784,0.002584558,0.000008288986,0.00006707849,0.0002775635,0.00001354848,0.001961659,0.9897794,0.0000194103,0.002313065,0.00001155221],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923236,0.003559688,0.002697127,0.00009728342,0.00002011921,0.0001020628,0.0001333703,0.00005212582,0.001014512],"genre_scores_gemma":[0.9951252,0.001642119,0.0025154,0.00002165656,0.000009961234,0.0000352466,0.0001129899,0.00001090117,0.0005265173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008194189,"threshold_uncertainty_score":0.003635168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06097591290692741,"score_gpt":0.401842975573094,"score_spread":0.3408670626661666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}