{"id":"W2155078044","doi":"10.1152/ajplung.90578.2008","title":"MMP9 modulates tight junction integrity and cell viability in human airway epithelia","year":2009,"lang":"en","type":"article","venue":"American Journal of Physiology-Lung Cellular and Molecular Physiology","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Heart, Lung, and Blood Institute","keywords":"MMP9; TIMP1; Proinflammatory cytokine; Tight junction; Cell biology; Matrix metalloproteinase; Epithelium; Adherens junction; Biology; Viability assay; Immunology; Chemistry; Cell; Inflammation; Downregulation and upregulation; Cadherin; Gene expression; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001226866,0.00009235294,0.0001197426,0.0001290666,0.0001685341,0.0002541355,0.00008521403,0.0001766789,0.001320539],"category_scores_gemma":[0.0001338194,0.00007918032,0.0001269893,0.0001096409,0.0001089143,0.000174436,0.0001275432,0.0003211572,0.0002434855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002347501,"about_ca_system_score_gemma":0.00008912775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008525163,"about_ca_topic_score_gemma":0.0008816321,"domain_scores_codex":[0.9998832,0.00003160683,0.000008793798,0.00001552099,0.00002746756,0.0000334083],"domain_scores_gemma":[0.9999535,0.00001061432,0.000009787891,0.000006649735,0.000009416343,0.000009975944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001551787,0.00003143354,0.0003509113,0.00001568976,0.000003970907,0.000038,0.00001805306,0.00001824791,0.9982267,0.00005063727,0.00002757326,0.00106368],"study_design_scores_gemma":[0.00002898439,0.0006063737,0.02372748,0.000006242477,0.00002352913,0.0003752903,0.00009119686,0.0008668565,0.9718788,0.0001095736,0.002280986,0.000004675417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970132,0.00173764,0.0004954538,0.00006527643,0.00001202083,0.000007993568,0.0001016092,0.00000977364,0.0005569057],"genre_scores_gemma":[0.9979511,0.0006647891,0.0002472648,0.00001767859,0.000004052384,0.000007031684,0.0001525592,0.000002108509,0.0009534232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001320539,"threshold_uncertainty_score":0.004417658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003458449807432034,"score_gpt":0.2248833056918373,"score_spread":0.2214248558844053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}