{"id":"W2155100666","doi":"10.1038/onc.2013.471","title":"The Polycomb group (PcG) protein EZH2 supports the survival of PAX3-FOXO1 alveolar rhabdomyosarcoma by repressing FBXO32 (Atrogin1/MAFbx)","year":2013,"lang":"en","type":"article","venue":"Oncogene","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Cancer Institute; Cancer Research UK; National Institutes of Health; Ministero della Salute; Associazione Italiana per la Ricerca sul Cancro; Sarcoma UK","keywords":"PRC2; Biology; EZH2; Gene knockdown; BMI1; Cancer research; Polycomb-group proteins; Rhabdomyosarcoma; Histone H3; Cellular differentiation; Molecular biology; Cell biology; Epigenetics; Stem cell; Gene expression; Repressor; Apoptosis; Genetics; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007720576,0.0002245151,0.0002052165,0.0000222934,0.0003275364,0.00009179475,0.0004495799,0.0001832945,0.00005069915],"category_scores_gemma":[0.0001404474,0.0001419438,0.0001788589,0.0001167017,0.0002245739,0.000009451441,0.0002172741,0.0001440644,0.00001382916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001543451,"about_ca_system_score_gemma":0.00007065322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003141368,"about_ca_topic_score_gemma":0.0000726348,"domain_scores_codex":[0.9981594,0.0002814105,0.000441375,0.0004001773,0.0003189726,0.0003986639],"domain_scores_gemma":[0.9984872,0.00006702999,0.00028905,0.0009072421,0.0001495452,0.00009996031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003077457,0.00006435769,0.002885923,0.00001035894,0.00006500237,0.000001169712,0.00003611665,0.000009830869,0.9671199,0.0001279312,0.001506505,0.0281421],"study_design_scores_gemma":[0.0003769202,0.0002657448,0.002276896,0.00001509782,0.00002750843,0.000003790584,0.00009746477,0.00008133311,0.8921851,0.0007271662,0.1037402,0.0002027984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827061,0.01205931,0.001680515,0.0009207769,0.0002523784,0.0006636877,0.00002856708,0.00001418339,0.001674477],"genre_scores_gemma":[0.9968552,0.0005498013,0.0007665022,0.0000852723,0.0002693504,0.0001087991,0.000142689,0.00003636257,0.001186004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1022337,"threshold_uncertainty_score":0.5788299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00588274728052763,"score_gpt":0.2298790665478935,"score_spread":0.2239963192673659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}