{"id":"W2155100666","doi":"10.1038/onc.2013.471","title":"The Polycomb group (PcG) protein EZH2 supports the survival of PAX3-FOXO1 alveolar rhabdomyosarcoma by repressing FBXO32 (Atrogin1/MAFbx)","year":2013,"lang":"en","type":"article","venue":"Oncogene","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Cancer Institute; Cancer Research UK; National Institutes of Health; Ministero della Salute; Associazione Italiana per la Ricerca sul Cancro; Sarcoma UK","keywords":"PRC2; Biology; EZH2; Gene knockdown; BMI1; Cancer research; Polycomb-group proteins; Rhabdomyosarcoma; Histone H3; Cellular differentiation; Molecular biology; Cell biology; Epigenetics; Stem cell; Gene expression; Repressor; Apoptosis; Genetics; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006565332,0.0001654685,0.0001247568,0.0001483195,0.0001416948,0.0001708516,0.00009845627,0.00008482244,0.001168333],"category_scores_gemma":[0.00005522924,0.00006724648,0.0001346906,0.00007863396,0.0001503275,0.00009837547,0.0002169605,0.0002067761,0.0002118066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001627632,"about_ca_system_score_gemma":0.0001361086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008317802,"about_ca_topic_score_gemma":0.00203652,"domain_scores_codex":[0.9999243,0.00000839411,0.00000681559,0.00001298143,0.00002796255,0.00001947786],"domain_scores_gemma":[0.9999673,0.000005111325,0.000008361507,0.000003963521,0.000003873028,0.000011424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003770735,0.000005621329,0.0004461527,0.00001435606,0.000002828612,0.00003621974,0.00001209283,0.00002815599,0.9987422,0.00007648621,0.00002368723,0.0005744856],"study_design_scores_gemma":[0.00001144025,0.0001115953,0.01675203,0.000002978255,0.0000122014,0.0002544807,0.00004455399,0.001047806,0.9792093,0.00005332536,0.002497806,0.00000242159],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971803,0.000554535,0.0008867899,0.00003621888,0.000008338822,0.000005464506,0.0001165746,0.00003155634,0.001180153],"genre_scores_gemma":[0.9977909,0.0002034744,0.0003198291,0.00001157157,0.000002997927,0.000006127138,0.0001912876,0.000003900671,0.001469891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001168333,"threshold_uncertainty_score":0.003908515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00588274728052763,"score_gpt":0.2298790665478935,"score_spread":0.2239963192673659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}