{"id":"W2155131464","doi":"10.1186/1752-0509-3-72","title":"Cascading signaling pathways improve the fidelity of a stochastically and deterministically simulated molecular RS latch","year":2009,"lang":"en","type":"article","venue":"BMC Systems Biology","topic":"Gene Regulatory Network Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Crosstalk; Computer science; Fidelity; High fidelity; Systems biology; Biological system; Topology (electrical circuits); Electronic engineering; Biology; Bioinformatics; Engineering; Electrical engineering; Telecommunications","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000415436,0.0003583917,0.000268349,0.0002030295,0.000202451,0.0003895344,0.0006111038,0.0004710632,0.001968872],"category_scores_gemma":[0.001861632,0.0001878114,0.0002619899,0.0001594158,0.0004739478,0.0004954413,0.0005603648,0.0005370544,0.0001523174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005086574,"about_ca_system_score_gemma":0.0004598491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008614094,"about_ca_topic_score_gemma":0.0007069578,"domain_scores_codex":[0.9998204,0.00003842919,0.0000140805,0.00003551571,0.00005529167,0.0000363077],"domain_scores_gemma":[0.9989958,0.0006255273,0.0001131011,0.0001255727,0.00006623846,0.00007371901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0003975772,0.0001940491,0.002965383,0.0001388078,0.00005714591,0.0002297987,0.0001369682,0.730612,0.238886,0.01454413,0.000224016,0.01161408],"study_design_scores_gemma":[0.00001814996,0.00008574328,0.0002142191,0.00000342378,0.00001491786,0.00002287415,0.000006787391,0.9422342,0.05614963,0.001018511,0.000223875,0.000007728296],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9016144,0.00009717484,0.09513464,0.0001097999,0.00002985095,0.00002486097,0.00002763654,0.0007372497,0.002224406],"genre_scores_gemma":[0.9940795,0.00002297637,0.005499873,0.00001176122,0.000001632357,0.00001140199,0.00001156407,0.00002278261,0.0003384887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001968872,"threshold_uncertainty_score":0.006586492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01291911316357507,"score_gpt":0.2509212976478232,"score_spread":0.2380021844842481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}