{"id":"W2155178263","doi":"10.1002/1520-6017(200102)90:2<124::aid-jps3>3.0.co;2-x","title":"Heat‐Induced Superaggregation of Amphotericin B Modifies Its Interaction with Serum Proteins and Lipoproteins and Stimulation of TNF‐α","year":2001,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Medical Research Council; Bristol-Myers Squibb","keywords":"Lipoprotein; Albumin; Chemistry; Stimulation; Triglyceride; Serum albumin; Circular dichroism; High-density lipoprotein; Cytokine; Absorption (acoustics); Low-density lipoprotein; Endocrinology; Pharmacology; Internal medicine; Cholesterol; Biochemistry; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001887535,0.0003132516,0.0002022881,0.0001516488,0.0001887622,0.0002148087,0.0001906935,0.0002907826,0.001626492],"category_scores_gemma":[0.0002584796,0.0001860513,0.0003692389,0.0001458282,0.0001982197,0.0001894403,0.0001936881,0.0006181048,0.0004621413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002275574,"about_ca_system_score_gemma":0.0001411166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004370289,"about_ca_topic_score_gemma":0.0004510646,"domain_scores_codex":[0.9998611,0.00004004804,0.00001155222,0.00001467404,0.00002164759,0.00005085833],"domain_scores_gemma":[0.9998261,0.00004951952,0.00004395323,0.00002720426,0.0000162951,0.0000369124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004416737,0.00003526769,0.0002066528,0.00002235482,0.00001164286,0.00006917014,0.00001929162,0.00003144984,0.9986088,0.00006653321,0.00003887486,0.0004482877],"study_design_scores_gemma":[0.00004162331,0.0002340888,0.007253985,0.000005625468,0.00002093135,0.000286184,0.0000257572,0.0005048409,0.9908006,0.00005121821,0.0007689786,0.000006310737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977674,0.0007077561,0.0008374376,0.000080708,0.00003028958,0.00001009736,0.00008484803,0.00001636853,0.0004650397],"genre_scores_gemma":[0.9982119,0.0002469165,0.0004396117,0.0000537401,0.00001328401,0.00001374115,0.0002436301,0.000007972676,0.0007692113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001626492,"threshold_uncertainty_score":0.005441129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08164555296381491,"score_gpt":0.3813039604500009,"score_spread":0.2996584074861859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}