{"id":"W2155207427","doi":"10.1021/ol063001q","title":"Asymmetric Syntheses of 1-Aryl-2,2,2-trifluoroethylamines via Diastereoselective 1,2-Addition of Arylmetals to 2-Methyl-<i>N</i>-(2,2,2-trifluoroethylidene)propane-2-sulfinamide","year":2007,"lang":"en","type":"article","venue":"Organic Letters","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Reagent; Propane; Aryl; Imine; Condensation; Adduct; Hydrochloride; Hydrate; Organic chemistry; Medicinal chemistry; Combinatorial chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004021383,0.000708684,0.0004998134,0.0003104347,0.0002947463,0.0002712234,0.0008602676,0.0006277634,0.002206212],"category_scores_gemma":[0.0003022426,0.0003106703,0.0003501808,0.000237568,0.000180018,0.0003913144,0.0003301899,0.0006886196,0.001462327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004343021,"about_ca_system_score_gemma":0.0006551208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007818073,"about_ca_topic_score_gemma":0.002895164,"domain_scores_codex":[0.9997126,0.00004057945,0.0000295639,0.00004732284,0.00005544014,0.0001144448],"domain_scores_gemma":[0.9998565,0.00001654377,0.00004736843,0.00001947664,0.00002910583,0.00003109583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002309571,0.0001476514,0.0001981997,0.0003788421,0.00003652157,0.0006166456,0.0001722555,0.0005369924,0.98311,0.001569659,0.0008218135,0.01218042],"study_design_scores_gemma":[0.00006197644,0.0003702447,0.0005882847,0.00001249809,0.00001969871,0.0003189317,0.00002441579,0.0006989047,0.9902959,0.00009200014,0.007498836,0.00001827142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9098929,0.004459331,0.05226009,0.0006006939,0.0004838636,0.000601032,0.002433124,0.0008809278,0.02838803],"genre_scores_gemma":[0.9634982,0.002843153,0.02309298,0.0001546351,0.0000716796,0.0002270644,0.001023312,0.0000946473,0.008994316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002206212,"threshold_uncertainty_score":0.007380486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04312451919720971,"score_gpt":0.3527636863643804,"score_spread":0.3096391671671707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}