{"id":"W2155207427","doi":"10.1021/ol063001q","title":"Asymmetric Syntheses of 1-Aryl-2,2,2-trifluoroethylamines via Diastereoselective 1,2-Addition of Arylmetals to 2-Methyl-<i>N</i>-(2,2,2-trifluoroethylidene)propane-2-sulfinamide","year":2007,"lang":"en","type":"article","venue":"Organic Letters","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Reagent; Propane; Aryl; Imine; Condensation; Adduct; Hydrochloride; Hydrate; Organic chemistry; Medicinal chemistry; Combinatorial chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002322979,0.0006602562,0.00109307,0.0008555733,0.0001652208,0.0000192062,0.0009887811,0.0005758934,0.002369233],"category_scores_gemma":[0.002910154,0.0006848507,0.0003270606,0.002853251,0.0004994014,0.0002706375,0.0002652113,0.00104815,0.0002655156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004102385,"about_ca_system_score_gemma":0.000163717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001316355,"about_ca_topic_score_gemma":0.00003178906,"domain_scores_codex":[0.995494,0.0002447351,0.00159959,0.0008628735,0.0007124999,0.001086296],"domain_scores_gemma":[0.99369,0.003755399,0.000842938,0.0007905271,0.0004482029,0.0004729807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005545261,0.0005001568,0.004951154,0.0002666946,0.0004500065,0.00009346076,0.0006543523,0.0000408868,0.9577382,0.00005169818,0.005002521,0.02969639],"study_design_scores_gemma":[0.001134915,0.0003304627,0.007028453,0.0000868213,0.0003542132,0.0001253875,0.0002009953,0.00002551009,0.9865392,0.0001032278,0.00346467,0.0006061283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888718,0.0009468317,0.004789271,0.001653354,0.001219154,0.0008476092,0.0001598781,0.0001797687,0.001332292],"genre_scores_gemma":[0.9948415,0.000144116,0.001510879,0.002456837,0.0005796373,0.00003564826,0.00004658557,0.0001410551,0.0002437509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02909026,"threshold_uncertainty_score":0.9995603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04312451919720971,"score_gpt":0.3527636863643804,"score_spread":0.3096391671671707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}