{"id":"W2155225646","doi":"10.1093/hmg/ddq560","title":"A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3","year":2011,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Center for Advancing Translational Sciences; National Center for Research Resources; National Institute on Aging; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; School of Medicine, Boston University","keywords":"IGFBP3; Biology; Locus (genetics); Genome-wide association study; Genetics; Genetic association; Single-nucleotide polymorphism; Insulin-like growth factor 2; Chromosome; Gene; Population; Insulin-like growth factor-binding protein; Endocrinology; Insulin-like growth factor; Growth factor; Gene expression; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004381987,0.0005467961,0.0005397198,0.0005318244,0.0004408447,0.0006270548,0.0003983443,0.0007642487,0.002456679],"category_scores_gemma":[0.001498734,0.0001868196,0.0007684533,0.001161789,0.0002728785,0.0001166397,0.0003428737,0.0005528925,0.0002778283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002290845,"about_ca_system_score_gemma":0.0003597192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00950925,"about_ca_topic_score_gemma":0.01011323,"domain_scores_codex":[0.9996967,0.00005948139,0.00001959289,0.0001240422,0.00005566251,0.00004453497],"domain_scores_gemma":[0.9993119,0.0002303654,0.0001817773,0.00005424145,0.00007665921,0.0001449107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008477638,0.0003012843,0.8916908,0.0003088919,0.005033603,0.003447484,0.0004402862,0.0002649044,0.05744082,0.0004888783,0.004418676,0.02768662],"study_design_scores_gemma":[0.0002392819,0.0001776521,0.9953982,0.00001729591,0.0008297416,0.001031332,0.00005886098,0.0003171845,0.000545345,0.0001820477,0.001189614,0.00001341582],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936652,0.002341098,0.001149299,0.0003111833,0.00008359857,0.00001923877,0.001498433,0.00007714921,0.0008547457],"genre_scores_gemma":[0.9951501,0.0007653498,0.0015422,0.0002293316,0.00008029702,0.00002656312,0.001290758,0.00002401511,0.0008914352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00950925,"threshold_uncertainty_score":0.01890779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03451512799788333,"score_gpt":0.2463547606919763,"score_spread":0.2118396326940929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}