{"id":"W2155246914","doi":"10.1084/jem.20091927","title":"Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in <i>Rag</i> -dependent immunodeficiency","year":2010,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"University of California, San Francisco; Fondation pour la Recherche Médicale; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Fondazione Cariplo; Manton Foundation; Dubai Harvard Foundation for Medical Research; National Institute of Allergy and Infectious Diseases; Joslin Diabetes Center; American Academy of Allergy Asthma and Immunology; GlaxoSmithKline; American Thoracic Society; National Science Foundation","keywords":"Severe combined immunodeficiency; Biology; Antibody; Immunology; Immunodeficiency; B cell; Adoptive cell transfer; Recombination-activating gene; B-cell activating factor; RAG2; Autoantibody; Immunoglobulin E; Plasma cell; Common variable immunodeficiency; Molecular biology; T cell; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001516077,0.000502077,0.0002334622,0.0006071097,0.0001046201,0.0002552333,0.0001731422,0.0004061774,0.0008138146],"category_scores_gemma":[0.0001634932,0.0002007272,0.0002182475,0.0001438291,0.000505207,0.0002037111,0.0002591775,0.0004158072,0.0001523941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001626426,"about_ca_system_score_gemma":0.00008176175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002703309,"about_ca_topic_score_gemma":0.0003009674,"domain_scores_codex":[0.9998405,0.00003383337,0.00002872291,0.00003566455,0.00003399288,0.00002724996],"domain_scores_gemma":[0.9997817,0.00003412242,0.0001026712,0.00002049597,0.000007894148,0.00005321652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001387275,0.00002976861,0.001901202,0.00003204968,0.000006958908,0.0004862365,0.00002456198,0.00007042397,0.9963582,0.00008474872,0.00001516727,0.0008518572],"study_design_scores_gemma":[0.00009742488,0.001638417,0.09899955,0.00003448376,0.0001032,0.02188193,0.0001117225,0.001945425,0.8729231,0.0002952058,0.001948394,0.00002112139],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981713,0.0006863127,0.0006349974,0.00002213225,0.000002277685,0.000006476836,0.00008964134,0.00003851512,0.0003482641],"genre_scores_gemma":[0.998795,0.0002804611,0.0005213331,0.00002186691,0.000004812281,0.000008673241,0.0001207533,0.0000111407,0.00023583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008138146,"threshold_uncertainty_score":0.002722502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00604016908738277,"score_gpt":0.2351646609584662,"score_spread":0.2291244918710835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}