{"id":"W2155246914","doi":"10.1084/jem.20091927","title":"Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in <i>Rag</i> -dependent immunodeficiency","year":2010,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"University of California, San Francisco; Fondation pour la Recherche Médicale; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Fondazione Cariplo; Manton Foundation; Dubai Harvard Foundation for Medical Research; National Institute of Allergy and Infectious Diseases; Joslin Diabetes Center; American Academy of Allergy Asthma and Immunology; GlaxoSmithKline; American Thoracic Society; National Science Foundation","keywords":"Severe combined immunodeficiency; Biology; Antibody; Immunology; Immunodeficiency; B cell; Adoptive cell transfer; Recombination-activating gene; B-cell activating factor; RAG2; Autoantibody; Immunoglobulin E; Plasma cell; Common variable immunodeficiency; Molecular biology; T cell; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001538123,0.0001864641,0.0004705474,0.0002061731,0.00009875518,0.000004046794,0.0004086943,0.0001286679,0.000146021],"category_scores_gemma":[0.00006490507,0.0001208373,0.00005846285,0.0002207071,0.0005663169,0.0001224169,0.0001027,0.0008286216,0.000005948409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000281483,"about_ca_system_score_gemma":0.00005688669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004667067,"about_ca_topic_score_gemma":0.000008498514,"domain_scores_codex":[0.9983159,0.0002312016,0.0009036919,0.0001332212,0.0001160868,0.000299913],"domain_scores_gemma":[0.9989347,0.0002478038,0.0005162624,0.0002455128,0.0000463689,0.000009329639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004822529,0.0002824134,0.000722713,0.00001698252,0.000008689125,0.000008658394,0.0100903,0.00006488324,0.987416,0.00007114289,0.000009931281,0.0008260951],"study_design_scores_gemma":[0.004496376,0.0007437759,0.00645368,0.0003140814,0.00001857999,0.0001862598,0.01570604,0.00001586656,0.9716963,0.00005648238,0.0001899717,0.0001225457],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8648961,0.1328445,0.00001443579,0.0001058504,0.001118515,0.0001583995,0.000001218919,0.000003905481,0.000857074],"genre_scores_gemma":[0.9987528,0.001052577,0.00002585406,0.0000921031,0.000008886303,0.000002633017,0.000001947989,0.00001206624,0.0000511033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1338567,"threshold_uncertainty_score":0.4927603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00604016908738277,"score_gpt":0.2351646609584662,"score_spread":0.2291244918710835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}