{"id":"W2155249636","doi":"10.1093/protein/gzs098","title":"TAT hitchhiker selection expanded to folding helpers, multimeric interactions and combinations with protein fragment complementation","year":2012,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Chromosomal translocation; Biology; Protein-fragment complementation assay; Protein folding; Protein design; Protein–protein interaction; Chemistry; Computational biology; Complementation; Biochemistry; Protein structure; Cell biology; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002166258,0.0001535808,0.0001579253,0.0002497777,0.000212292,0.00004486617,0.00001978367,0.00003747598,0.00004191975],"category_scores_gemma":[0.00003671045,0.0001325305,0.00002014657,0.0003474889,0.0000173134,0.0002264505,0.00001785263,0.000189568,0.000006867208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001196422,"about_ca_system_score_gemma":0.00002537177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001625514,"about_ca_topic_score_gemma":0.00001256066,"domain_scores_codex":[0.9991023,0.00005142661,0.0001553548,0.0001927341,0.0002060257,0.0002921892],"domain_scores_gemma":[0.9995833,0.00003685863,0.00003550952,0.00004047403,0.00009822834,0.0002056108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004366932,0.0002151257,0.006203884,0.0001684802,0.0001059547,0.000001147785,0.0007731169,0.001008068,0.9838287,0.000585323,0.00009749916,0.006576063],"study_design_scores_gemma":[0.004257038,0.003557851,0.07749796,0.0007379726,0.00016929,0.0005313237,0.0004667673,0.3421087,0.5608781,0.00005958108,0.008968288,0.000767114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.668215,0.0001435836,0.32954,0.0004291644,0.0000287349,0.001536008,9.412852e-7,0.00008191781,0.00002469071],"genre_scores_gemma":[0.9341198,0.00001383894,0.06432138,0.00003521898,0.0000944905,0.0006049592,0.00001427273,0.00002269394,0.000773404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4229505,"threshold_uncertainty_score":0.5404439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.027963408772214,"score_gpt":0.294160605564694,"score_spread":0.26619719679248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}