{"id":"W2155267526","doi":"10.1186/1476-4598-12-88","title":"Combined p21-activated kinase and farnesyltransferase inhibitor treatment exhibits enhanced anti-proliferative activity on melanoma, colon and lung cancer cell lines","year":2013,"lang":"en","type":"article","venue":"Molecular Cancer","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Associazione Italiana per la Ricerca sul Cancro","keywords":"Farnesyltransferase; Farnesyltransferase inhibitor; Cancer research; Biology; Cancer; Melanoma; Cell growth; Prenylation; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007765258,0.0003299573,0.0002941949,0.000345822,0.0001534797,0.0001970129,0.0001373577,0.0002105261,0.00222111],"category_scores_gemma":[0.00005978961,0.00008917178,0.0003556545,0.0003135614,0.0001282391,0.0001052162,0.00009868591,0.0005571306,0.0006385685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002039809,"about_ca_system_score_gemma":0.0002277202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001700146,"about_ca_topic_score_gemma":0.002339694,"domain_scores_codex":[0.9998935,0.00001132882,0.00001042595,0.00002420254,0.00003416062,0.00002638369],"domain_scores_gemma":[0.9999205,0.00001824804,0.00001356033,0.00001282629,0.0000114453,0.00002342885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001766121,0.00006945471,0.0001970574,0.00004762385,0.000007570871,0.00003635609,0.00001408489,0.00006401123,0.9977254,0.00002586302,0.0001165279,0.001519333],"study_design_scores_gemma":[0.00001427848,0.0005784392,0.003270458,0.000003345011,0.00001344629,0.0001070645,0.00001485918,0.0002767764,0.9943392,0.000008030443,0.00137184,0.000002453981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897328,0.002928027,0.001456759,0.0001036817,0.00004907028,0.00004443572,0.001902811,0.0001694229,0.003613073],"genre_scores_gemma":[0.9880363,0.001751306,0.002365064,0.00005507762,0.00001060657,0.00006655665,0.002991624,0.00003082879,0.004692748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00222111,"threshold_uncertainty_score":0.007430315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007620298550295447,"score_gpt":0.2519173026243646,"score_spread":0.2442970040740691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}