{"id":"W2155276106","doi":"10.1176/appi.ajp.2014.13101306","title":"Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette’s Syndrome and OCD","year":2014,"lang":"en","type":"article","venue":"American Journal of Psychiatry","topic":"Obsessive-Compulsive Spectrum Disorders","field":"Psychology","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cilag; David Geffen School of Medicine, University of California, Los Angeles; National Center for Advancing Translational Sciences; National Human Genome Research Institute; National Institute on Drug Abuse; National Institute of Mental Health; St. George's, University of London; Canadian Institutes of Health Research; Eli Lilly Canada; Department of Psychiatry, University of Toronto; Stanley Center for Psychiatric Research, Broad Institute; University of California, Irvine; Directorate for Biological Sciences; Centers for Disease Control and Prevention; Medical Research Council; Servier; Universidad Pontificia Bolivariana; Julius-Maximilians-Universität Würzburg; Universität zu Köln; Otsuka Pharmaceutical; National Institute of Neurological Disorders and Stroke; Universität Zürich; H. Lundbeck A/S; Hospital for Sick Children; Universidade de São Paulo; Hebrew University of Jerusalem; Bundesministerium für Bildung und Forschung; Universiteit van Amsterdam; AstraZeneca; European Commission; Vrije Universiteit Amsterdam; University of Oxford; Child and Family Research Institute; Fondation FondaMental; Universidad de Antioquia; Sanofi; Broad Institute; University of California, Los Angeles; Pfizer; Università degli Studi di Milano; Allison Family Foundation; Jazz Pharmaceuticals; Deutsche Forschungsgemeinschaft; Conselho Nacional de Desenvolvimento Científico e Tecnológico; McGill University; National Institutes of Health; American Academy of Child and Adolescent Psychiatry; Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles; University of Cincinnati; Ministero dell’Istruzione, dell’Università e della Ricerca; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; York University; Eberhard Karls Universität Tübingen; University of California, San Diego; Johns Hopkins University; Cincinnati Children's Hospital Medical Center; F. Hoffmann-La Roche; Wayne State University; National Cancer Institute; Grifols; University College London; University of Southern California; Brigham and Women's Hospital; McLean Hospital; University of British Columbia; Eli Lilly and Company; Koninklijke Nederlandse Akademie van Wetenschappen; University of Illinois at Urbana-Champaign; Michael Smith Health Research BC; Rheinische Friedrich-Wilhelms-Universität Bonn; International OCD Foundation; Rijksuniversiteit Groningen; DNA Genotek; FP7 Health; University of Toronto; American Psychiatric Publishing; Bristol-Myers Squibb; Teva Pharmaceutical Industries; National Science Foundation; University of Cape Town; Massachusetts General Hospital; University of California, San Francisco; GlaxoSmithKline; National Institute on Alcohol Abuse and Alcoholism; University of New South Wales; Yale University","keywords":"Genome-wide association study; Tourette syndrome; Single-nucleotide polymorphism; Tics; Genetic association; Genetic architecture; Genetics; Biology; Phenotype; Psychology; Gene; Neuroscience; Psychiatry; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004167355,0.0003535446,0.0008422352,0.0005478447,0.0002566046,0.0001022313,0.0005400485,0.0001041302,0.0008243173],"category_scores_gemma":[0.0002077295,0.0003311317,0.0002852971,0.0007511266,0.0008770843,0.0001605433,0.00006125411,0.0006651149,0.0001139016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004975813,"about_ca_system_score_gemma":0.0001141615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002819899,"about_ca_topic_score_gemma":0.0001218411,"domain_scores_codex":[0.9970515,0.000563705,0.001014541,0.0004352355,0.0003885056,0.0005464769],"domain_scores_gemma":[0.9967752,0.0007908735,0.001398511,0.0005255524,0.0001593992,0.0003505434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007464069,0.0001239582,0.9940541,0.0000164014,0.0003616112,0.00002145079,0.0004787064,0.0001680864,0.00001397236,0.0007275159,0.000893013,0.003066476],"study_design_scores_gemma":[0.001488238,0.001360226,0.9882699,0.00003253592,0.0002572804,0.0005147762,0.001546148,0.00001248937,4.60534e-7,0.004361947,0.001795035,0.0003609144],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834175,0.002084964,0.006904386,0.004972797,0.0007184916,0.0001520955,0.00002051635,0.00003548305,0.001693825],"genre_scores_gemma":[0.9874835,0.00001834132,0.01072681,0.001040295,0.0005039813,0.000005007098,0.00001178796,0.00007118462,0.0001390866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005784217,"threshold_uncertainty_score":0.9999141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02536130213106922,"score_gpt":0.3454909922511081,"score_spread":0.3201296901200388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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