{"id":"W2155276106","doi":"10.1176/appi.ajp.2014.13101306","title":"Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette’s Syndrome and OCD","year":2014,"lang":"en","type":"article","venue":"American Journal of Psychiatry","topic":"Obsessive-Compulsive Spectrum Disorders","field":"Psychology","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cilag; David Geffen School of Medicine, University of California, Los Angeles; National Center for Advancing Translational Sciences; National Human Genome Research Institute; National Institute on Drug Abuse; National Institute of Mental Health; St. George's, University of London; Canadian Institutes of Health Research; Eli Lilly Canada; Department of Psychiatry, University of Toronto; Stanley Center for Psychiatric Research, Broad Institute; University of California, Irvine; Directorate for Biological Sciences; Centers for Disease Control and Prevention; Medical Research Council; Servier; Universidad Pontificia Bolivariana; Julius-Maximilians-Universität Würzburg; Universität zu Köln; Otsuka Pharmaceutical; National Institute of Neurological Disorders and Stroke; Universität Zürich; H. Lundbeck A/S; Hospital for Sick Children; Universidade de São Paulo; Hebrew University of Jerusalem; Bundesministerium für Bildung und Forschung; Universiteit van Amsterdam; AstraZeneca; European Commission; Vrije Universiteit Amsterdam; University of Oxford; Child and Family Research Institute; Fondation FondaMental; Universidad de Antioquia; Sanofi; Broad Institute; University of California, Los Angeles; Pfizer; Università degli Studi di Milano; Allison Family Foundation; Jazz Pharmaceuticals; Deutsche Forschungsgemeinschaft; Conselho Nacional de Desenvolvimento Científico e Tecnológico; McGill University; National Institutes of Health; American Academy of Child and Adolescent Psychiatry; Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles; University of Cincinnati; Ministero dell’Istruzione, dell’Università e della Ricerca; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; York University; Eberhard Karls Universität Tübingen; University of California, San Diego; Johns Hopkins University; Cincinnati Children's Hospital Medical Center; F. Hoffmann-La Roche; Wayne State University; National Cancer Institute; Grifols; University College London; University of Southern California; Brigham and Women's Hospital; McLean Hospital; University of British Columbia; Eli Lilly and Company; Koninklijke Nederlandse Akademie van Wetenschappen; University of Illinois at Urbana-Champaign; Michael Smith Health Research BC; Rheinische Friedrich-Wilhelms-Universität Bonn; International OCD Foundation; Rijksuniversiteit Groningen; DNA Genotek; FP7 Health; University of Toronto; American Psychiatric Publishing; Bristol-Myers Squibb; Teva Pharmaceutical Industries; National Science Foundation; University of Cape Town; Massachusetts General Hospital; University of California, San Francisco; GlaxoSmithKline; National Institute on Alcohol Abuse and Alcoholism; University of New South Wales; Yale University","keywords":"Genome-wide association study; Tourette syndrome; Single-nucleotide polymorphism; Tics; Genetic association; Genetic architecture; Genetics; Biology; Phenotype; Psychology; Gene; Neuroscience; Psychiatry; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001507547,0.0006074353,0.0004604044,0.001500352,0.0004736008,0.0007867935,0.0004298034,0.0006776497,0.005799986],"category_scores_gemma":[0.003463017,0.0003484853,0.001218594,0.001207925,0.000578316,0.0002824953,0.0009131726,0.0006392355,0.0002540874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003158281,"about_ca_system_score_gemma":0.0002773342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004434203,"about_ca_topic_score_gemma":0.005640558,"domain_scores_codex":[0.9987942,0.0003604618,0.0001215794,0.0004897105,0.0001386434,0.00009543328],"domain_scores_gemma":[0.9967418,0.001644753,0.0008200994,0.0003188618,0.0002490252,0.0002254278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005607961,0.00004325614,0.9800253,0.00005566447,0.001856885,0.0007699788,0.0001824898,0.0002807718,0.01107724,0.0002251053,0.0002292581,0.004693234],"study_design_scores_gemma":[0.00002345243,0.00007350485,0.9977363,0.00001178862,0.0003706285,0.0007004236,0.00006496902,0.0004008929,0.000293482,0.0001653165,0.0001536721,0.000005541322],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971002,0.0008196916,0.000998714,0.0001564951,0.00001300123,0.000009529245,0.0002854554,0.00003826208,0.0005785887],"genre_scores_gemma":[0.9985954,0.0001793733,0.0006308437,0.00008433976,0.00001560496,0.000007104148,0.0003422598,0.000009200038,0.0001359366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005799986,"threshold_uncertainty_score":0.01940286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02536130213106922,"score_gpt":0.3454909922511081,"score_spread":0.3201296901200388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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