{"id":"W2155293017","doi":"10.1093/cid/cis337","title":"Fidaxomicin Attains High Fecal Concentrations With Minimal Plasma Concentrations Following Oral Administration in Patients With Clostridium difficile Infection","year":2012,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; Université de Montréal; Hôpital Maisonneuve-Rosemont; University of Calgary","funders":"Viropharma","keywords":"Medicine; Clostridium difficile; Fidaxomicin; Feces; Clostridium Infections; C difficile; Gastroenterology; Internal medicine; Fecal bacteriotherapy; Microbiology; Plasma concentration; Antibiotics; Vancomycin; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005665174,0.0003776764,0.001064687,0.000255282,0.0003199229,0.0005683164,0.0001467773,0.0004648157,0.0004633894],"category_scores_gemma":[0.002372553,0.0002255886,0.0001733945,0.000329836,0.0003002028,0.000291068,0.0001926953,0.0007041358,0.0001786428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004318235,"about_ca_system_score_gemma":0.0003390055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000311074,"about_ca_topic_score_gemma":0.0007652011,"domain_scores_codex":[0.9996371,0.0001556936,0.00003107784,0.000049218,0.0000701242,0.00005677559],"domain_scores_gemma":[0.9994339,0.0001621326,0.0001884532,0.00002487977,0.00005272229,0.0001377885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05114182,0.001909043,0.3889244,0.0009293061,0.0004040043,0.006270023,0.0006994616,0.001221588,0.262215,0.0002375208,0.005736791,0.280311],"study_design_scores_gemma":[0.001533302,0.05025499,0.8704139,0.0001235477,0.0003334979,0.01648659,0.0004161693,0.002239113,0.05045885,0.0002263071,0.007435684,0.00007801564],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943343,0.003498354,0.0006004522,0.0003076439,0.00003541572,0.00003743911,0.00006948473,0.00007626544,0.001040563],"genre_scores_gemma":[0.9985745,0.0004073865,0.0005756315,0.0001496584,0.00003073004,0.00001696847,0.00008084033,0.000006124533,0.0001581708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001064687,"threshold_uncertainty_score":0.003133118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02846032274421208,"score_gpt":0.3361331444957847,"score_spread":0.3076728217515726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}