{"id":"W2155304716","doi":"10.2174/1874609811104010008","title":"Damaged Proteins Bearing L-Isoaspartyl Residues and Aging: A Dynamic Equilibrium Between Generation of Isomerized Forms and Repair by PIMT","year":2011,"lang":"en","type":"article","venue":"Current Aging Science","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"","keywords":"Deamidation; Enzyme; Chemistry; Biochemistry; Methyltransferase; Posttranslational modification; Cell biology; Biology; Methylation; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002512055,0.000631988,0.0008025736,0.001029753,0.0001961974,0.0007009472,0.0003729997,0.0005155907,0.0009038532],"category_scores_gemma":[0.0002645103,0.0001673035,0.000526168,0.001027416,0.000227826,0.0009284388,0.0004073579,0.0006741009,0.0005991919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004281946,"about_ca_system_score_gemma":0.0003899472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004248704,"about_ca_topic_score_gemma":0.0005169673,"domain_scores_codex":[0.9998759,0.0000168973,0.00002251189,0.00003073758,0.00003466697,0.0000192202],"domain_scores_gemma":[0.9998653,0.00002978189,0.00005297951,0.000003768664,0.00003381463,0.0000143491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00107015,0.0001329775,0.005932048,0.04282289,0.0007172049,0.00494484,0.0005917129,0.001087574,0.2135739,0.004767776,0.02000059,0.7043583],"study_design_scores_gemma":[0.00002919809,0.0006423107,0.04299847,0.002564601,0.000955848,0.02359779,0.00050155,0.000902725,0.08275598,0.004416047,0.8405197,0.0001157058],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.006761731,0.9905193,0.0008318963,0.0003266001,0.0002066974,0.0000081761,0.000119649,0.00003519807,0.001190821],"genre_scores_gemma":[0.01883854,0.9775696,0.001224847,0.0003001166,0.00033405,0.00001504175,0.0003208862,0.000006339076,0.001390478],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001029753,"threshold_uncertainty_score":0.003106833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08647645672338428,"score_gpt":0.3477731177150242,"score_spread":0.26129666099164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}