{"id":"W2155305990","doi":"10.1126/science.1124256","title":"A Critical Role for the Innate Immune Signaling Molecule IRAK-4 in T Cell Activation","year":2006,"lang":"en","type":"article","venue":"Science","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research","funders":"","keywords":"Innate immune system; Cell biology; Acquired immune system; Biology; Signal transduction; Lipid raft; Immune system; T cell; Regulator; ZAP70; Innate lymphoid cell; T-cell receptor; Immunology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003349236,0.0006937648,0.0003147973,0.0003347317,0.0004858382,0.0006149943,0.0004587377,0.0005612118,0.002404638],"category_scores_gemma":[0.0003404977,0.0001845847,0.0003179823,0.0001453701,0.0007388104,0.0007448309,0.0005672986,0.0008260782,0.000932596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006111996,"about_ca_system_score_gemma":0.0005225121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002187381,"about_ca_topic_score_gemma":0.0001255965,"domain_scores_codex":[0.9998057,0.0000504028,0.00001860472,0.00003281493,0.00003808902,0.00005433967],"domain_scores_gemma":[0.9998544,0.00002273777,0.00003628187,0.00001770204,0.0000255251,0.00004339507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005040998,0.0000539328,0.0004656138,0.0001857022,0.000009765712,0.0004219514,0.0000236873,0.0002485902,0.9911101,0.001506612,0.0001866658,0.005283294],"study_design_scores_gemma":[0.0001632047,0.000683231,0.008200974,0.00003844988,0.00005356774,0.00243411,0.0001020584,0.001993238,0.9657472,0.002899061,0.01765973,0.00002518043],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9432728,0.03105856,0.01688184,0.001415414,0.0003582429,0.00007958984,0.0002882939,0.0003018703,0.006343302],"genre_scores_gemma":[0.9852803,0.004950593,0.006205355,0.0001382046,0.0001463322,0.00005118873,0.0002155523,0.00001727466,0.002995033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002404638,"threshold_uncertainty_score":0.008044302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007319329745454724,"score_gpt":0.2473456982866069,"score_spread":0.2400263685411522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}