{"id":"W2155325230","doi":"10.1124/jpet.108.144824","title":"M5 Muscarinic Receptor Knockout Mice Show Reduced Morphine-Induced Locomotion but Increased Locomotion after Cholinergic Antagonism in the Ventral Tegmental Area","year":2008,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Mecamylamine; Ventral tegmental area; Muscarinic acetylcholine receptor; Knockout mouse; Chemistry; Endocrinology; Internal medicine; Dopamine; Conditioned place preference; Antagonist; Morphine; Atropine; Pharmacology; Muscarinic acetylcholine receptor M4; Neuroscience; Receptor; Biology; Dopaminergic; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003549909,0.0002158487,0.0002350945,0.00008436565,0.0001366335,0.0000176514,0.0002069834,0.0001921178,0.0001984315],"category_scores_gemma":[0.00000445637,0.0001636635,0.000142993,0.00008083189,0.0001256821,0.00002634668,0.00005097725,0.0003271767,0.000002368561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006802547,"about_ca_system_score_gemma":0.0000938904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000139497,"about_ca_topic_score_gemma":0.000001340821,"domain_scores_codex":[0.9986341,0.0002821326,0.0004298399,0.0002107047,0.0001820212,0.0002611771],"domain_scores_gemma":[0.9994938,0.00002117102,0.0002421847,0.00009476638,0.00005629242,0.00009177555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001057163,0.0005274559,0.0003196925,0.000005253818,0.0001211881,0.00004379877,0.001042078,0.00004296909,0.996186,0.000003136585,0.0003001876,0.0003510757],"study_design_scores_gemma":[0.002817144,0.001151291,0.001179809,0.00001321345,0.0000600684,0.00072316,0.0009912121,0.0001806967,0.9918764,0.00001806534,0.0008123656,0.0001765853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954478,0.002840097,0.00007142517,0.0003897636,0.0009851633,0.0002304763,0.000008257097,0.000004477928,0.00002258455],"genre_scores_gemma":[0.9959759,0.001109281,0.0002514962,0.001762802,0.0007968796,0.00002225001,0.00003055929,0.00002069076,0.0000301814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00430961,"threshold_uncertainty_score":0.6674002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02741788975602588,"score_gpt":0.2962029458777145,"score_spread":0.2687850561216886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}