{"id":"W2155352554","doi":"10.1101/gad.1279805","title":"Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control","year":2005,"lang":"en","type":"article","venue":"Genes & Development","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":227,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec; McGill University","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Rad50; G2-M DNA damage checkpoint; Biology; DNA damage; DNA methylation; DNA repair; CHEK1; Cell biology; Arginine; Methylation; Exonuclease; DNA; Genetics; Molecular biology; Cell cycle checkpoint; DNA-binding protein; Gene; Cell cycle; Amino acid; DNA polymerase; Gene expression; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002586539,0.0001575745,0.0001785898,0.00004693483,0.00006068443,0.00000924466,0.0001095683,0.000154458,0.00004175981],"category_scores_gemma":[0.00002396528,0.0001625237,0.00007916699,0.00007659738,0.00003193867,0.000006284349,0.00003878191,0.00002925097,0.000008027637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000707072,"about_ca_system_score_gemma":0.0001797619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004368365,"about_ca_topic_score_gemma":0.0000275356,"domain_scores_codex":[0.9988738,0.00002473869,0.0004166133,0.0003142737,0.0001555929,0.0002149457],"domain_scores_gemma":[0.9993398,0.000009695752,0.0001990076,0.0002344223,0.0001602743,0.00005680805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001382357,0.00003995519,0.0001829465,0.00002203902,0.0001226945,5.817413e-8,0.0001680872,0.0005936498,0.9257538,0.00001100052,0.005112581,0.06785496],"study_design_scores_gemma":[0.001064629,0.00006881426,0.001688685,0.00000906781,0.00002196595,0.000001027256,0.00001419279,0.0004928075,0.700405,0.00001544366,0.2960787,0.0001396607],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9429768,0.003291111,0.05158947,0.00101834,0.0001656615,0.0006909352,0.000063513,0.00001753397,0.0001866408],"genre_scores_gemma":[0.981289,0.0001776,0.01571745,0.0002215064,0.0002379595,0.0001341165,0.0006504239,0.00003008069,0.001541822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2909661,"threshold_uncertainty_score":0.6627523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009025853251149631,"score_gpt":0.2486526104003249,"score_spread":0.2396267571491752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}