{"id":"W2155352554","doi":"10.1101/gad.1279805","title":"Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control","year":2005,"lang":"en","type":"article","venue":"Genes & Development","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":227,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec; McGill University","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Rad50; G2-M DNA damage checkpoint; Biology; DNA damage; DNA methylation; DNA repair; CHEK1; Cell biology; Arginine; Methylation; Exonuclease; DNA; Genetics; Molecular biology; Cell cycle checkpoint; DNA-binding protein; Gene; Cell cycle; Amino acid; DNA polymerase; Gene expression; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001393654,0.0002722268,0.0002711052,0.0001190608,0.0001572351,0.0003081253,0.0001757518,0.0002213273,0.0008760948],"category_scores_gemma":[0.0002628594,0.0001578326,0.0001529233,0.00008175287,0.0002576117,0.0002228753,0.0002373961,0.000453537,0.0006784464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002319917,"about_ca_system_score_gemma":0.0001274822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003719284,"about_ca_topic_score_gemma":0.0004594305,"domain_scores_codex":[0.999848,0.00002599766,0.00001421574,0.0000425583,0.00003834935,0.00003081409],"domain_scores_gemma":[0.9997768,0.00003333105,0.00007303794,0.00004044312,0.00002521831,0.00005118392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004501099,0.000003597839,0.0002337759,0.000009461432,0.000001321097,0.00004734864,0.000004810389,0.00002982146,0.998988,0.00004847274,0.00001005489,0.0005782817],"study_design_scores_gemma":[0.000006709248,0.00006917778,0.007122522,0.000001940364,0.000004658978,0.0004555687,0.00001802949,0.0005306769,0.9902309,0.00005054016,0.001505907,0.000003464815],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936865,0.001250664,0.003829742,0.0001081236,0.00001997767,0.000008452957,0.000131466,0.0001052723,0.0008597941],"genre_scores_gemma":[0.9968155,0.0002945818,0.001245954,0.00001329476,0.000004595669,0.00000464447,0.0001995815,0.00002287122,0.001399008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008760948,"threshold_uncertainty_score":0.00293082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009025853251149631,"score_gpt":0.2486526104003249,"score_spread":0.2396267571491752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}