{"id":"W2155361286","doi":"10.1002/prot.22305","title":"Thermodynamics and dynamics of amyloid peptide oligomerization are sequence dependent","year":2008,"lang":"en","type":"article","venue":"Proteins Structure Function and Bioinformatics","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Montréal","funders":"Fudan University","keywords":"Chemistry; Fibril; Nucleation; Molecular dynamics; Kinetics; Peptide; Biophysics; Amyloid (mycology); Crystallography; Biochemistry; Computational chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003786872,0.0001424664,0.0001999601,0.0001079477,0.000141279,0.00001530276,0.00003004053,0.00008779654,0.00002935742],"category_scores_gemma":[0.00003095498,0.0001036529,0.00003218502,0.000137155,0.0001393546,0.0001780451,0.00003703042,0.0001223425,0.000002056459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005403438,"about_ca_system_score_gemma":0.00008530458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002532822,"about_ca_topic_score_gemma":0.00002937501,"domain_scores_codex":[0.9991821,0.0000139078,0.0002410445,0.0001124329,0.0002927636,0.0001577626],"domain_scores_gemma":[0.9993797,0.00001104129,0.0001613198,0.0001507997,0.0001314455,0.0001656759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002983906,0.0005833108,0.8648472,0.004669729,0.005818218,0.0001141574,0.002599935,0.0001426048,0.009895663,0.004890474,0.00006911193,0.1033857],"study_design_scores_gemma":[0.006258811,0.002034206,0.7504063,0.0003688539,0.0008211912,0.001416429,0.002125914,0.2293277,0.003469757,0.003133228,0.00007235834,0.0005652122],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904528,0.0004416011,0.007468889,0.0001272569,0.00004246706,0.0007394566,0.0001935615,0.00004104543,0.0004928794],"genre_scores_gemma":[0.9945446,0.0005272584,0.004523675,0.00007781307,0.0000234541,0.00001096107,0.0002454218,0.00001060724,0.0000361858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2291851,"threshold_uncertainty_score":0.4226844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01728095118054731,"score_gpt":0.2469652567553455,"score_spread":0.2296843055747982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}