{"id":"W2155395980","doi":"10.1128/aac.50.2.694-701.2006","title":"Discordances between Interpretation Algorithms for Genotypic Resistance to Protease and Reverse Transcriptase Inhibitors of Human Immunodeficiency Virus Are Subtype Dependent","year":2006,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bayer (Canada); AIDS Vancouver","funders":"","keywords":"Nelfinavir; Saquinavir; Indinavir; Virology; Stavudine; Reverse transcriptase; Biology; Amprenavir; Ritonavir; Lamivudine; Genotyping; Concordance; Protease; Drug resistance; Genotype; Virus; Sida; Viral load; Genetics; Viral disease; Polymerase chain reaction; Antiretroviral therapy; HIV-1 protease; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007867256,0.0001624499,0.0002871232,0.00008104571,0.0001230548,0.00002247068,0.00004464384,0.00004729579,0.00001342991],"category_scores_gemma":[0.00000384917,0.0001340799,0.0000585945,0.0000918085,0.00006158238,0.00006654831,0.0000104512,0.00004544561,0.000001204224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003225805,"about_ca_system_score_gemma":0.000024003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001474857,"about_ca_topic_score_gemma":0.00006462519,"domain_scores_codex":[0.9991453,0.00001411052,0.0002929299,0.0002703225,0.0001081385,0.0001692409],"domain_scores_gemma":[0.9996582,0.00001006031,0.0001160923,0.0001067271,0.00005245635,0.00005641165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002462934,0.001227305,0.425088,0.0009808085,0.0003787779,0.00003308848,0.005856351,0.000002725847,0.5220473,0.0000877021,0.01915608,0.02267894],"study_design_scores_gemma":[0.008769512,0.0005151997,0.3336105,0.0009875488,0.0003114947,0.000007723355,0.0003941847,0.00002452923,0.6403229,0.0002779156,0.01425761,0.0005208182],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957976,0.0001679717,0.0008674686,0.001931896,0.00004542177,0.001014412,0.0001093581,0.00001626361,0.00004964845],"genre_scores_gemma":[0.9943866,0.0001356129,0.002446196,0.0003933353,0.00005966561,0.00003142261,0.00009833826,0.0000203696,0.002428431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1182756,"threshold_uncertainty_score":0.5467622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01488638392648385,"score_gpt":0.2718370485688829,"score_spread":0.2569506646423991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}