{"id":"W2155448933","doi":"10.1016/j.neurobiolaging.2015.08.022","title":"Brain-derived neurotrophic factor and TrkB expression in the “oldest-old,” the 90+ Study: correlation with cognitive status and levels of soluble amyloid-beta","year":2015,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; National Institute on Aging; National Institutes of Health; Alzheimer Society","keywords":"Neuropathology; Tropomyosin receptor kinase B; Dementia; Brain-derived neurotrophic factor; Psychology; Neurotrophic factors; Neurodegeneration; Internal medicine; Alzheimer's disease; Neuroscience; Pathology; Endocrinology; Medicine; Disease; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002814885,0.0003034562,0.0003437347,0.0005352002,0.0004169915,0.0008465378,0.0001688953,0.0003454796,0.0007586252],"category_scores_gemma":[0.0007475712,0.0002492,0.0002973928,0.0005415427,0.0002661374,0.000342834,0.0002839895,0.0005400039,0.0002004203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001279158,"about_ca_system_score_gemma":0.0001329125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003729507,"about_ca_topic_score_gemma":0.00441271,"domain_scores_codex":[0.9998964,0.00002267428,0.0000131302,0.00002688691,0.00001462644,0.00002621135],"domain_scores_gemma":[0.9996552,0.0000468869,0.000100637,0.00002871416,0.00005039416,0.0001181254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002689876,0.0001538562,0.9916574,0.00001285754,0.0001654283,0.0002845168,0.0002807254,0.00002565719,0.002892557,0.0000215619,0.0001462755,0.001669301],"study_design_scores_gemma":[0.00002346633,0.0002060731,0.9986053,0.000001719543,0.00008262345,0.0003888485,0.0002973901,0.00004465578,0.0001582971,0.00002092392,0.0001673563,0.000003406562],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996071,0.0001049951,0.00001531817,0.000009987431,0.000005262233,0.000001360302,0.00009521403,6.963874e-7,0.0001600249],"genre_scores_gemma":[0.9993836,0.00009728181,0.00001868889,0.00001815993,0.00001156019,0.000002870906,0.0001904847,0.000001243204,0.0002760886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003729507,"threshold_uncertainty_score":0.007415593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06353775714522972,"score_gpt":0.3236022816115499,"score_spread":0.2600645244663202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}