{"id":"W2155477225","doi":"10.1186/1743-422x-7-68","title":"Characterization of the HIV-1 integrase chromatin- and LEDGF/p75-binding abilities by mutagenic analysis within the catalytic core domain of integrase","year":2010,"lang":"en","type":"article","venue":"Virology Journal","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Manitoba Medical Service Foundation; Manitoba Health Research Council","keywords":"Integrase; Biology; Chromatin; Virology; Human immunodeficiency virus (HIV); Computational biology; Genetics; Integrase inhibitor; Core (optical fiber); DNA; Antiretroviral therapy; Physics; Viral load","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001333222,0.0003868081,0.0001469006,0.0001965504,0.0001484688,0.0001771893,0.0002601887,0.000198643,0.0007137732],"category_scores_gemma":[0.0001376835,0.0001002422,0.0002590288,0.0001352778,0.000257894,0.00009752021,0.0001410983,0.0003850308,0.0002144268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003406371,"about_ca_system_score_gemma":0.0002163546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002468091,"about_ca_topic_score_gemma":0.002895507,"domain_scores_codex":[0.9998939,0.00001156627,0.000008908666,0.00001448994,0.00004838791,0.00002271924],"domain_scores_gemma":[0.9998704,0.00002623993,0.00004579543,0.00001233225,0.00001772983,0.00002740415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002026065,0.000009972209,0.0001303794,0.00001287913,0.000003349925,0.00003179151,0.000006818997,0.00003443986,0.99944,0.00003124885,0.000004493747,0.0002743496],"study_design_scores_gemma":[0.000004939175,0.00005866615,0.003293616,0.00000327408,0.00002202319,0.0002090834,0.00001855563,0.0005858773,0.9948833,0.00001747676,0.000899899,0.000003232277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954627,0.0003455133,0.003443018,0.00003036035,0.00001012285,0.00001993227,0.000185494,0.00001759361,0.0004851786],"genre_scores_gemma":[0.9961057,0.0002073239,0.002447559,0.00002647613,0.000003402036,0.00001235158,0.0004326277,0.00001612509,0.0007483584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002468091,"threshold_uncertainty_score":0.004907489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006877283639979851,"score_gpt":0.2321274587231534,"score_spread":0.2252501750831735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}