{"id":"W2155488701","doi":"10.1038/emboj.2009.122","title":"Structural basis of error‐prone replication and stalling at a thymine base by human DNA polymerase ι","year":2009,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Argonne National Laboratory; Canadian Institutes of Health Research","keywords":"Biology; Thymine; DNA replication; DNA polymerase; Replication (statistics); Genetics; DNA; DNA polymerase II; Polymerase; Base pair; DNA clamp; Molecular biology; Polymerase chain reaction; Gene; Virology; Reverse transcriptase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003302955,0.00009820408,0.000102473,0.00002151317,0.0001857512,0.00001874302,0.0001451387,0.00004778457,0.00004908668],"category_scores_gemma":[0.00003690831,0.00006976408,0.00005431117,0.00003643335,0.00004623329,0.000005160028,0.00005182922,0.00009297504,6.04117e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001497166,"about_ca_system_score_gemma":0.00001679587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006553045,"about_ca_topic_score_gemma":0.000005304998,"domain_scores_codex":[0.9992858,0.00006544872,0.000204863,0.0001742474,0.0001259227,0.000143761],"domain_scores_gemma":[0.9993549,0.000005914954,0.0001758902,0.0003415616,0.00004763561,0.00007410841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006488734,0.00001565414,0.0001279208,0.000003102975,0.00002289689,0.000002009369,0.00007556283,0.000006988738,0.9953704,0.00006196868,0.0006021651,0.003646381],"study_design_scores_gemma":[0.0004320626,0.0002988555,0.00122818,0.00001178635,0.00002601591,0.0002738048,0.00005992055,0.0001574822,0.9965918,0.0005989328,0.0002333972,0.0000877831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976509,0.001134642,0.0002543851,0.000653986,0.00003228322,0.00008281134,0.00001255578,0.000005654212,0.0001727812],"genre_scores_gemma":[0.9985943,0.00006948115,0.0004261829,0.0002232719,0.0001263517,0.000001398533,0.00003065976,0.00001009981,0.0005182924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003558597,"threshold_uncertainty_score":0.2844897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01550296242643884,"score_gpt":0.2710168551523884,"score_spread":0.2555138927259495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}