{"id":"W2155493718","doi":"10.4049/jimmunol.1102757","title":"Substrate Rigidity Regulates Human T Cell Activation and Proliferation","year":2012,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":323,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Common Fund; National Institutes of Health; National Eye Institute; York University; University of Pennsylvania","keywords":"CD28; Ex vivo; T cell; Materials science; Cytotoxic T cell; CD8; Cell biology; Cell growth; T-cell receptor; Priming (agriculture); Cell adhesion; Biophysics; Chemistry; Cell; In vitro; Biology; Immunology; Immune system; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001006611,0.00006315002,0.0001548743,0.0000882634,0.0001000728,0.00000953466,0.00006884005,0.00006875933,0.0003219768],"category_scores_gemma":[0.00004105478,0.00003800867,0.00003315321,0.00006942673,0.0001252516,0.0001646363,0.00002094258,0.0003553062,0.00000655426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005400321,"about_ca_system_score_gemma":0.00004294522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001540951,"about_ca_topic_score_gemma":0.000001731457,"domain_scores_codex":[0.9992433,0.0001945149,0.0002187721,0.0000361102,0.0001388587,0.0001684491],"domain_scores_gemma":[0.9993891,0.0001008677,0.0001851665,0.0001349106,0.0001459238,0.00004404282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006349433,0.0000892322,0.009435545,0.00001107113,0.00006870634,0.000001206028,0.0008409041,0.00000156028,0.9869331,0.0001180277,0.0001563066,0.001709372],"study_design_scores_gemma":[0.001007056,0.0005781193,0.2555117,0.00001872211,0.00004424794,0.0005205588,0.0002201182,0.000007977848,0.7405515,0.0003859847,0.001119498,0.0000345781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964826,0.001112235,0.00004927023,0.001145158,0.00008891134,0.000138229,2.062774e-7,0.000005510011,0.0009778744],"genre_scores_gemma":[0.9980025,0.0003793994,0.00005420277,0.00006064686,0.0002912376,0.000001029027,0.000001743633,0.000008745662,0.00120051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2463817,"threshold_uncertainty_score":0.352542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03637093820036858,"score_gpt":0.3153096164480318,"score_spread":0.2789386782476633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}