{"id":"W2155493718","doi":"10.4049/jimmunol.1102757","title":"Substrate Rigidity Regulates Human T Cell Activation and Proliferation","year":2012,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":323,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Common Fund; National Institutes of Health; National Eye Institute; York University; University of Pennsylvania","keywords":"CD28; Ex vivo; T cell; Materials science; Cytotoxic T cell; CD8; Cell biology; Cell growth; T-cell receptor; Priming (agriculture); Cell adhesion; Biophysics; Chemistry; Cell; In vitro; Biology; Immunology; Immune system; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001632166,0.0002574214,0.0001305307,0.0001964599,0.0001328321,0.0004588834,0.000102175,0.0002312342,0.00229297],"category_scores_gemma":[0.0003758393,0.0001622587,0.0001126851,0.0001777704,0.0001464494,0.0001756546,0.0002085496,0.0002369362,0.0005619461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001769109,"about_ca_system_score_gemma":0.00008552965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002130224,"about_ca_topic_score_gemma":0.0002582907,"domain_scores_codex":[0.9997979,0.00005040894,0.00001620456,0.00003420726,0.00005974268,0.00004162406],"domain_scores_gemma":[0.9997584,0.0001008132,0.00006773094,0.00001933152,0.00002490019,0.00002882331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001861455,0.00001487595,0.001025736,0.00001959487,0.000003650249,0.00005378027,0.00001892252,0.0001852294,0.9959481,0.00003083632,0.00004008336,0.002473104],"study_design_scores_gemma":[0.00001648011,0.000532314,0.05977203,0.00001252743,0.00002092784,0.0004612568,0.0000931843,0.002323316,0.9332119,0.0000909084,0.003449614,0.00001553992],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944078,0.002238013,0.0008918748,0.00004962253,0.00001059279,0.00001197644,0.0001838852,0.00002955147,0.002176762],"genre_scores_gemma":[0.9974752,0.0008566152,0.0005679397,0.00003410882,0.00001069578,0.0000136054,0.0002275439,0.00001249811,0.0008017524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00229297,"threshold_uncertainty_score":0.007670701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03637093820036858,"score_gpt":0.3153096164480318,"score_spread":0.2789386782476633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}