{"id":"W2155509846","doi":"10.1158/0008-5472.can-12-3678","title":"Heterogeneity of Neoplastic Stem Cells: Theoretical, Functional, and Clinical Implications","year":2013,"lang":"en","type":"review","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Cancer Research UK","keywords":"Biology; Neoplastic transformation; Stem cell; Somatic cell; Cancer; Cancer stem cell; Somatic evolution in cancer; Genome; Cancer research; Genetics; Malignant transformation; Carcinogenesis; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005890671,0.000201538,0.0006127403,0.00008796146,0.000100792,0.00004691818,0.0003076474,0.0003806881,0.00009350548],"category_scores_gemma":[0.0001322847,0.0001673222,0.0002550632,0.0001638851,0.0008637033,0.000001824198,0.0004523047,0.0003844909,0.00003183828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005568835,"about_ca_system_score_gemma":0.001006778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003737787,"about_ca_topic_score_gemma":0.00003588051,"domain_scores_codex":[0.9980983,0.0002840087,0.0005305225,0.0005781254,0.0001906605,0.0003184036],"domain_scores_gemma":[0.9980878,0.0005613271,0.0001525825,0.0006277772,0.0003626228,0.0002079041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003389878,0.0001405734,0.0001447984,0.004217187,0.0004240359,0.000001104239,0.000004281123,0.000005199232,0.001461792,0.005197897,0.02593601,0.9624332],"study_design_scores_gemma":[0.0001638623,0.0002329934,0.0000303068,0.0005751341,0.0001680753,0.000006980469,0.000006114438,0.000003004073,0.0008122765,0.000198436,0.9976192,0.0001836654],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004823584,0.9934253,0.0001645952,0.00005632211,0.0002621119,0.000695301,0.0004296913,0.000003823649,0.0001392592],"genre_scores_gemma":[0.001855617,0.9967179,0.00005977955,0.00002679405,0.0005491853,0.0004541704,0.00009543065,0.0000453078,0.0001958044],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9716831,"threshold_uncertainty_score":0.6823202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1926037494874433,"score_gpt":0.473244517130978,"score_spread":0.2806407676435347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}