{"id":"W2155547273","doi":"10.1124/mol.106.026716","title":"Distinct Signaling Profiles of β1 and β2 Adrenergic Receptor Ligands toward Adenylyl Cyclase and Mitogen-Activated Protein Kinase Reveals the Pluridimensionality of Efficacy","year":2006,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":286,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Research in Immunology and Cancer","funders":"GlaxoSmithKline","keywords":"Adenylyl cyclase; Receptor; Protein kinase A; Effector; Signal transduction; MAPK/ERK pathway; Intrinsic activity; Inverse agonist; G protein-coupled receptor; Functional selectivity; Ligand (biochemistry); cAMP-dependent pathway; Biology; Chemistry; Cell biology; Biochemistry; Pharmacology; Kinase; Agonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00037343,0.0002377292,0.0003358416,0.00005303757,0.00009541056,0.00001201504,0.0001567167,0.0001831108,0.0001112889],"category_scores_gemma":[0.00006605995,0.0001871207,0.0001064625,0.000122694,0.0002665951,0.000005362904,0.0001739615,0.0001348754,5.100646e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009604561,"about_ca_system_score_gemma":0.00007165186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000602814,"about_ca_topic_score_gemma":0.00000162465,"domain_scores_codex":[0.9984561,0.000233142,0.0004411738,0.0004328655,0.0001713408,0.0002653983],"domain_scores_gemma":[0.9992436,0.00005019195,0.0002758971,0.0001946336,0.0001498841,0.00008579635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003761723,0.0001267539,0.000240925,0.00009217796,0.0001193999,0.00001068844,0.00005487058,0.0001179374,0.9981027,0.0001941571,0.0002748737,0.0002893259],"study_design_scores_gemma":[0.001345474,0.0003304789,0.0003248408,0.00004188085,0.00009151518,0.00001337112,0.00003566108,0.00006685827,0.9965702,0.0001871023,0.0007952678,0.0001973784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953035,0.003194606,0.0004742234,0.0002115761,0.0001322639,0.0005878044,0.00005380426,0.00001103839,0.00003125015],"genre_scores_gemma":[0.9986656,0.00005506359,0.0007450536,0.0001020055,0.0001341852,0.00006294761,0.000111972,0.0000290237,0.00009420356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003362112,"threshold_uncertainty_score":0.7630559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009112526610595445,"score_gpt":0.2492321039072224,"score_spread":0.2401195772966269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}