{"id":"W2155562629","doi":"10.1002/anie.201400870","title":"Design of Monodisperse and Well‐Defined Polypeptide‐Based Polyvalent Inhibitors of Anthrax Toxin","year":2014,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Allergy and Infectious Diseases","keywords":"Valency; Anthrax toxin; Rational design; Peptide; Linker; Chemistry; Small molecule; Ligand (biochemistry); Receptor; Dendrimer; Dispersity; Biochemistry; Combinatorial chemistry; Biology; Fusion protein; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003698558,0.0005008106,0.0003871071,0.0002555728,0.0001655454,0.0005654656,0.0004638702,0.0003861063,0.0006448022],"category_scores_gemma":[0.0002871813,0.0003193384,0.0001874214,0.000210748,0.0003072397,0.0003663939,0.0002454785,0.0007132041,0.0003934323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009597012,"about_ca_system_score_gemma":0.0004027168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003805261,"about_ca_topic_score_gemma":0.0008689463,"domain_scores_codex":[0.9997764,0.00003453612,0.00002889186,0.00005582346,0.00006491314,0.00003942246],"domain_scores_gemma":[0.9998098,0.00004096563,0.0000678662,0.00001354133,0.00003204647,0.00003578276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008523616,0.00006067111,0.00006301414,0.0000681953,0.00000784791,0.00003625627,0.00002006593,0.001759456,0.9943134,0.000819689,0.00008123423,0.002685037],"study_design_scores_gemma":[0.00004329313,0.0002629453,0.0001446977,0.000006298906,0.00001419193,0.00004508312,0.000008887143,0.004753161,0.9912167,0.00007254592,0.003423222,0.000009072483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9014676,0.004394958,0.08579259,0.0002608094,0.0001097539,0.0005504742,0.0005109994,0.0002928603,0.006620057],"genre_scores_gemma":[0.9382304,0.003018623,0.05147885,0.0001924224,0.00002708628,0.0005770938,0.0005915543,0.00009909894,0.005785006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009597012,"threshold_uncertainty_score":0.006963074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0136337174144116,"score_gpt":0.2552267449114535,"score_spread":0.2415930274970419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}