{"id":"W2155570055","doi":"10.1085/jgp.20028586","title":"Cysteine Mutagenesis and Computer Modeling of the S6 Region of an Intermediate Conductance IKCa Channel","year":2002,"lang":"en","type":"article","venue":"The Journal of General Physiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Cysteine; Conductance; Mutagenesis; Chemistry; Channel (broadcasting); Biophysics; Site-directed mutagenesis; Biology; Mutation; Biochemistry; Physics; Computer science; Gene; Mutant; Telecommunications","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001269511,0.0004676313,0.0004021151,0.0001875642,0.0002972891,0.0002780238,0.0004662979,0.0003930889,0.001306704],"category_scores_gemma":[0.0002337404,0.0001737369,0.0004000249,0.0002552691,0.0001620997,0.0001757524,0.0001581261,0.000492923,0.0003146095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000444829,"about_ca_system_score_gemma":0.0005379231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002658549,"about_ca_topic_score_gemma":0.002062744,"domain_scores_codex":[0.999946,0.00001263603,0.000004457453,0.00001190281,0.00001676866,0.000008182373],"domain_scores_gemma":[0.9999239,0.00002114614,0.00001659792,0.000007165537,0.00001778633,0.0000133607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.000708474,0.0002717865,0.002116071,0.0002316227,0.00005453712,0.001020048,0.0002364353,0.1781583,0.8014566,0.00538054,0.0005933389,0.009772225],"study_design_scores_gemma":[0.0001231234,0.0004526383,0.00360642,0.00001919863,0.00005410872,0.0003198774,0.0001530506,0.8258879,0.163965,0.001185533,0.004204222,0.00002893162],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9569032,0.0001595571,0.03894168,0.00007731417,0.00001912693,0.00009808844,0.000877798,0.0004972907,0.002425809],"genre_scores_gemma":[0.951665,0.0003453397,0.04491534,0.0000215269,0.000005247131,0.0001055571,0.001901234,0.0001012334,0.0009395502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002658549,"threshold_uncertainty_score":0.005286157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02429790575777235,"score_gpt":0.2276562404697834,"score_spread":0.2033583347120111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}