{"id":"W2155582980","doi":"10.1101/gr.137224.112","title":"Targeted gene silencing in mouse germ cells by insertion of a homologous DNA into a piRNA generating locus","year":2012,"lang":"en","type":"article","venue":"Genome Research","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Naito Foundation","keywords":"Piwi-interacting RNA; Biology; Retrotransposon; Transposable element; Gene silencing; Genetics; Gene; Homologous recombination; RNA interference; RNA; Cell biology; Genome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009993416,0.0001015926,0.0001606148,0.0000542172,0.0002300693,0.00003138699,0.000238126,0.0001101126,0.0003499051],"category_scores_gemma":[0.00008110473,0.00004841268,0.0000485472,0.0007254856,0.0000719419,0.00009692205,0.0001612429,0.0002096111,0.0000563331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001048641,"about_ca_system_score_gemma":0.00002873817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002641217,"about_ca_topic_score_gemma":0.0007234583,"domain_scores_codex":[0.9982459,0.0002734644,0.0002942219,0.0002348147,0.0003741143,0.0005775177],"domain_scores_gemma":[0.9994278,0.0001635828,0.00004744918,0.00008256325,0.0001293391,0.0001492892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001040081,0.0001700204,0.002573827,0.0000100889,0.00000597105,0.000001366524,0.001219534,0.00005601525,0.9896823,0.00001205099,0.00003578921,0.00622266],"study_design_scores_gemma":[0.0001544511,0.0002390489,0.0336325,0.000008440681,0.000002591318,0.0000042192,0.0004557856,0.0002610524,0.9641677,0.0001505887,0.0007773954,0.0001462903],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975654,0.001739577,0.00001141692,0.0002258622,0.00004698137,0.0002475697,0.00004703609,0.00001746914,0.00009869609],"genre_scores_gemma":[0.998858,0.0001411131,0.0004189233,0.00002530885,0.0002301904,0.00003998338,0.00007206277,0.000001774543,0.0002126622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03105867,"threshold_uncertainty_score":0.3992747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03743429295819898,"score_gpt":0.2781656286736807,"score_spread":0.2407313357154817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}