{"id":"W2155602420","doi":"10.1152/ajpendo.00108.2011","title":"<i>O</i>-linked β-<i>N</i>-acetylglucosamine supports p38 MAPK activation by high glucose in glomerular mesangial cells","year":2011,"lang":"en","type":"article","venue":"American Journal of Physiology-Endocrinology and Metabolism","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Diabetes Canada; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Phosphorylation; Kinase; Protein kinase B; Mesangial cell; p38 mitogen-activated protein kinases; MAPK/ERK pathway; Cell biology; Chemistry; Protein kinase C; Protein kinase A; Signal transduction; Molecular biology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001294221,0.0004003683,0.0002181014,0.0001394974,0.000133536,0.0002206548,0.0001466561,0.0001384431,0.0008360035],"category_scores_gemma":[0.00008037759,0.0001426667,0.0003271851,0.0001305833,0.0001917122,0.0001832212,0.0001838067,0.0005852894,0.0002706316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002380516,"about_ca_system_score_gemma":0.0001930373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009105278,"about_ca_topic_score_gemma":0.001152598,"domain_scores_codex":[0.9998708,0.00001812849,0.00001429696,0.00002068421,0.00003096645,0.00004509418],"domain_scores_gemma":[0.999926,0.000007251967,0.00002075906,0.00001026743,0.000008735479,0.00002703529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001820326,0.00004418968,0.0001674974,0.00003097891,0.000003325218,0.00003411966,0.00001529589,0.00003685555,0.9988966,0.00004487504,0.00003819928,0.0005059415],"study_design_scores_gemma":[0.00003509149,0.0003719301,0.007623946,0.000005715279,0.00001218485,0.0001001081,0.00004478304,0.0009257014,0.9896403,0.00005713767,0.00117896,0.000004206923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966568,0.0007244212,0.001085133,0.0001056361,0.00003402518,0.00001376678,0.0002279554,0.00005138942,0.001100854],"genre_scores_gemma":[0.997108,0.0005754569,0.0008101758,0.00005184662,0.00001358858,0.00002791831,0.0003846051,0.000008121359,0.00102021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009105278,"threshold_uncertainty_score":0.002796769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007795113181330624,"score_gpt":0.2336248201990305,"score_spread":0.2258297070176998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}