{"id":"W2155612281","doi":"10.1111/j.1600-6143.2004.00530.x","title":"RNA Interference: A Potent Tool for Gene-Specific Therapeutics","year":2004,"lang":"en","type":"review","venue":"American Journal of Transplantation","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":false,"ca_institutions":"Robarts Clinical Trials; Lawson Health Research Institute; London Health Sciences Centre; Western University","funders":"Roche Organ Transplant Research Foundation; Kidney Foundation of Canada; London Health Sciences Centre; Lawson Health Research Institute; Heart and Stroke Foundation of Canada","keywords":"RNA interference; Small interfering RNA; RNA silencing; Gene silencing; DNA-directed RNA interference; RNA; Computational biology; Small hairpin RNA; Medicine; Gene; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001739244,0.000272499,0.0007115367,0.0001355485,0.00004014523,0.0000357417,0.0003354476,0.0001327781,0.000004841713],"category_scores_gemma":[0.000004831487,0.0002133608,0.0006524777,0.00009993756,0.00009148475,0.000007268497,0.000008589283,0.0001858116,0.000004803153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000541317,"about_ca_system_score_gemma":0.0003752587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003775231,"about_ca_topic_score_gemma":0.000002269481,"domain_scores_codex":[0.9986601,0.00008076303,0.0007038276,0.0002230515,0.000142459,0.0001898165],"domain_scores_gemma":[0.9987047,0.0000319818,0.0008201567,0.0001793507,0.0002091098,0.00005474288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000280943,0.00004544001,0.000001946433,0.001173912,0.0004232676,0.00001506943,0.0001294276,0.00002879779,0.003273097,0.000009393328,0.00006381443,0.9945549],"study_design_scores_gemma":[0.001448622,0.007715522,0.00003059283,0.01089215,0.002800923,0.002087473,0.0002354614,0.000002751869,0.01350262,0.00008596727,0.960268,0.0009299476],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004345521,0.9291415,0.06564046,0.00002042663,0.0003753231,0.0002939298,0.0001564608,0.000003377333,0.00002303809],"genre_scores_gemma":[0.007000031,0.9895133,0.002621604,0.0000786243,0.0003933129,0.00002037806,0.0002986462,0.00003797775,0.00003609972],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9936249,"threshold_uncertainty_score":0.8700602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.034418845508381,"score_gpt":0.3182568863197742,"score_spread":0.2838380408113932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}