{"id":"W2155626151","doi":"10.1038/msb.2011.71","title":"Systematic exploration of synergistic drug pairs","year":2011,"lang":"en","type":"article","venue":"Molecular Systems Biology","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":327,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"National Human Genome Research Institute; National Institute of General Medical Sciences; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu; National Institute of Mental Health; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health","keywords":"Drug; Biology; Computational biology; Antifungal drug; Antifungal drugs; Pharmacology; Promiscuity; Bioavailability; Drug discovery; Drug development; Genetics; Bioinformatics; Candida albicans","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001856533,0.0009757111,0.001760428,0.003989901,0.0006993605,0.001233847,0.0007439407,0.0005869701,0.004133902],"category_scores_gemma":[0.005973287,0.000675857,0.00223601,0.002211787,0.0006357282,0.001442928,0.001382058,0.000616242,0.0003782398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006640786,"about_ca_system_score_gemma":0.001805658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005473645,"about_ca_topic_score_gemma":0.001042684,"domain_scores_codex":[0.9987547,0.0004468081,0.00009372414,0.0002738016,0.0003214575,0.0001095361],"domain_scores_gemma":[0.9964259,0.002418248,0.0004223738,0.0003593345,0.0002511925,0.0001228225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002928687,0.001191977,0.07846285,0.006110094,0.003830106,0.002904982,0.0004052551,0.3822918,0.05009495,0.08566915,0.009985661,0.3761245],"study_design_scores_gemma":[0.0004481574,0.002316629,0.01991391,0.0002985964,0.003183659,0.002544868,0.0003957639,0.770873,0.0317336,0.143085,0.02504855,0.0001582748],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8380083,0.01082438,0.1189999,0.0007161325,0.00008515393,0.0005904353,0.003885706,0.001210787,0.02567928],"genre_scores_gemma":[0.9314102,0.002086246,0.06076607,0.0002101947,0.00003437469,0.0003736649,0.003569704,0.00008683749,0.00146259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004133902,"threshold_uncertainty_score":0.01382929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04421310378962579,"score_gpt":0.2785228367357592,"score_spread":0.2343097329461334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}