{"id":"W2155682641","doi":"10.1128/aac.02159-12","title":"HIV-1 Dynamics and Coreceptor Usage in Maraviroc-Treated Patients with Ongoing Replication","year":2012,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver","funders":"Agence Nationale de Recherches sur le Sida et les Hépatites Virales","keywords":"Maraviroc; Viral quasispecies; V3 loop; Tropism; CCR5 receptor antagonist; Biology; Virology; Mutation; Viral replication; Population; Selection (genetic algorithm); Viral evolution; Human immunodeficiency virus (HIV); Tissue tropism; Genetics; Virus; Medicine; Gene; Chemokine; RNA; Chemokine receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003567616,0.0002749688,0.0004150263,0.0005185913,0.0003937409,0.0006309189,0.000196213,0.0004629485,0.000814858],"category_scores_gemma":[0.002060666,0.0002228343,0.0001971717,0.0003306927,0.0002626707,0.0004581205,0.0002088301,0.0005281105,0.000181952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002627649,"about_ca_system_score_gemma":0.0001597978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007955802,"about_ca_topic_score_gemma":0.000724066,"domain_scores_codex":[0.9997397,0.00007401274,0.00002540844,0.00005321235,0.0000427495,0.00006485544],"domain_scores_gemma":[0.9993001,0.0001983267,0.000231362,0.00004420437,0.00006155844,0.0001644605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001894131,0.0001870636,0.972749,0.00002616174,0.00006154417,0.001830519,0.0005390792,0.0002305248,0.01064998,0.00008113511,0.0001349244,0.01161585],"study_design_scores_gemma":[0.0000678441,0.002571842,0.9887654,0.00002139067,0.00007126483,0.004931653,0.0004261865,0.001007827,0.001574532,0.0001008085,0.0004460753,0.00001531553],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994532,0.0002400441,0.00002886875,0.00001898003,0.000001560322,0.000004486963,0.00002221461,0.00000281399,0.0002278552],"genre_scores_gemma":[0.9997788,0.00006342954,0.000039211,0.00002284555,0.000006615835,0.000002708006,0.00003126147,0.000001120738,0.00005395099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000814858,"threshold_uncertainty_score":0.002725959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008202227955528392,"score_gpt":0.2345892193507153,"score_spread":0.2263869913951869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}