{"id":"W2155690692","doi":"10.1146/annurev.genet.36.061102.093104","title":"Genetic Engineering Using Homologous Recombination","year":2002,"lang":"en","type":"review","venue":"Annual Review of Genetics","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":517,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McGill University","keywords":"Recombineering; Homologous recombination; Biology; FLP-FRT recombination; Genetics; Non-allelic homologous recombination; Recombination; Genetic recombination; Plasmid; Homologous chromosome; Chromosome; Cre-Lox recombination; Bacterial artificial chromosome; Computational biology; Gene; Genome; Transgene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007658369,0.001086302,0.001756038,0.001512271,0.0004021295,0.001269217,0.001012789,0.0009584251,0.001722247],"category_scores_gemma":[0.0004501422,0.0003758173,0.0005108633,0.001772851,0.0007870252,0.000912223,0.0008290831,0.00174978,0.00533038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000825239,"about_ca_system_score_gemma":0.0005519902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004266117,"about_ca_topic_score_gemma":0.0003238679,"domain_scores_codex":[0.9992098,0.0001535106,0.00005923656,0.0001841656,0.0003291769,0.00006412737],"domain_scores_gemma":[0.9998671,0.00002842883,0.00003528321,0.00002427485,0.00002880369,0.00001606997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001127683,0.0002385823,0.000452645,0.005616886,0.0001171448,0.0007738734,0.0002096475,0.001508347,0.4195569,0.03816311,0.01209686,0.5211533],"study_design_scores_gemma":[0.00003043161,0.0002404412,0.0005844006,0.000350456,0.00006387959,0.002698473,0.00004929369,0.0007380045,0.1671194,0.007488371,0.820584,0.00005277473],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02063118,0.6549991,0.2600793,0.00198926,0.002286868,0.0005907941,0.0007770891,0.001629055,0.05701728],"genre_scores_gemma":[0.09232824,0.7280332,0.1382562,0.001367476,0.000608971,0.0006059775,0.00189855,0.0002108867,0.0366905],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001756038,"threshold_uncertainty_score":0.005987585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02169169360148817,"score_gpt":0.2945495892952055,"score_spread":0.2728578956937173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}