{"id":"W2155783473","doi":"10.1039/c5ob01794g","title":"Design of a fluorescent ligand targeting the S-adenosylmethionine binding site of the histone methyltransferase MLL1","year":2015,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Structural Genomics Consortium; Toronto Public Health","funders":"National Institutes of Health; National Institute of General Medical Sciences; Wellcome Trust","keywords":"Chemistry; Methyltransferase; Ligand (biochemistry); Fluorescence; Binding site; Lysine; Biochemistry; Methylation; Amino acid; DNA; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003250098,0.0004152821,0.0002796492,0.0002460587,0.0003050879,0.0003841903,0.0007120106,0.000702145,0.001360838],"category_scores_gemma":[0.0002655937,0.0002333242,0.0002664029,0.0001559957,0.0003076354,0.0002760255,0.000310227,0.0005819069,0.0006026502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001108172,"about_ca_system_score_gemma":0.000567884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00129358,"about_ca_topic_score_gemma":0.001787425,"domain_scores_codex":[0.9998205,0.00004168181,0.00001154469,0.0000322635,0.00004991148,0.00004405538],"domain_scores_gemma":[0.9998567,0.00002837042,0.00003077336,0.000009472416,0.00002345322,0.00005115356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001309823,0.0001010536,0.0001080409,0.00006584114,0.000007271854,0.00007548854,0.00002732851,0.001827761,0.9926911,0.0007426454,0.0001218993,0.004100687],"study_design_scores_gemma":[0.00006422984,0.0005231986,0.0001823968,0.000005452954,0.000008866723,0.00009922606,0.00001895629,0.005142636,0.9902812,0.00005750655,0.003604459,0.00001181261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9374528,0.001203232,0.05462588,0.0009380504,0.00006448458,0.0005368431,0.0004429009,0.0004000093,0.004335771],"genre_scores_gemma":[0.937483,0.0007528315,0.05492937,0.0002562453,0.00001936174,0.0003100062,0.0004107258,0.00002661302,0.005811902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001360838,"threshold_uncertainty_score":0.008040369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01493417964439058,"score_gpt":0.2505583322067859,"score_spread":0.2356241525623953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}