{"id":"W2155807206","doi":"10.1128/iai.71.2.845-849.2003","title":"Induction by Sphingomyelinase of Shiga Toxin Receptor and Shiga Toxin 2 Sensitivity in Human Microvascular Endothelial Cells","year":2003,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Globotriaosylceramide; Shiga toxin; Sphingomyelin; Biology; Ceramide; Sphingomyelin phosphodiesterase; Microbiology; Endothelial stem cell; Lipopolysaccharide; Shiga-like toxin; Molecular biology; Biochemistry; Escherichia coli; Immunology; Apoptosis; Internal medicine; Medicine; Cholesterol; Fabry disease; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007590358,0.0001349193,0.0001845645,0.00007120809,0.0001310318,0.00002327501,0.00002843652,0.0001675707,0.00002034219],"category_scores_gemma":[0.0001061547,0.0001421538,0.00005544718,0.00009937735,0.00009674829,0.00001530544,0.00004295628,0.0001851904,8.847159e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001113279,"about_ca_system_score_gemma":0.0000220292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001492708,"about_ca_topic_score_gemma":0.0001977939,"domain_scores_codex":[0.9990451,0.0003052001,0.0002177075,0.0002169101,0.00006706854,0.0001480289],"domain_scores_gemma":[0.9996074,0.00001493569,0.00008606647,0.0001871466,0.00004926757,0.00005520218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003005968,0.00009850098,0.006449969,0.00002549862,0.0000202914,4.000893e-7,0.0001469559,0.00001151142,0.9919532,0.00005558927,0.00008908732,0.001118966],"study_design_scores_gemma":[0.0009120951,0.0001028134,0.00815642,0.00001717522,0.00001437337,0.00001528902,0.0001091515,0.000006681705,0.9765063,0.00003544328,0.01397852,0.0001457365],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998477,0.0005412475,0.0004308675,0.00001189018,0.0002224307,0.0001349002,0.0000167189,0.000009117364,0.0001558051],"genre_scores_gemma":[0.9988599,0.0007243319,0.0001316669,0.00006817955,0.00008485398,0.00000529018,0.00004476573,0.00001236044,0.00006868497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01544687,"threshold_uncertainty_score":0.5796865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007728907291224257,"score_gpt":0.2277487436466441,"score_spread":0.2200198363554199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}