{"id":"W2155807206","doi":"10.1128/iai.71.2.845-849.2003","title":"Induction by Sphingomyelinase of Shiga Toxin Receptor and Shiga Toxin 2 Sensitivity in Human Microvascular Endothelial Cells","year":2003,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Globotriaosylceramide; Shiga toxin; Sphingomyelin; Biology; Ceramide; Sphingomyelin phosphodiesterase; Microbiology; Endothelial stem cell; Lipopolysaccharide; Shiga-like toxin; Molecular biology; Biochemistry; Escherichia coli; Immunology; Apoptosis; Internal medicine; Medicine; Cholesterol; Fabry disease; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001626013,0.0001787528,0.0002165521,0.0001954351,0.0001132839,0.0002752781,0.0000819262,0.0002651863,0.001478456],"category_scores_gemma":[0.0001745966,0.0001453103,0.0003241134,0.0001408737,0.0000941705,0.0001586305,0.000170965,0.0004103037,0.0003795043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002356767,"about_ca_system_score_gemma":0.0001135789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006401946,"about_ca_topic_score_gemma":0.0005202772,"domain_scores_codex":[0.9998156,0.00004598701,0.00001758855,0.00002509216,0.00003960281,0.00005614209],"domain_scores_gemma":[0.9998912,0.00002383549,0.00002167809,0.00002081448,0.00002537248,0.00001706053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008799491,0.0000199777,0.0001787673,0.00001281184,0.000003306845,0.00006692538,0.00001817244,0.00001725727,0.9991979,0.00003716053,0.00001259108,0.0003470785],"study_design_scores_gemma":[0.00002490986,0.0007175572,0.01622045,0.00000631086,0.0000138985,0.0004543744,0.00007255099,0.0007798017,0.9800744,0.00004554318,0.001583096,0.000007089045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962468,0.001202523,0.001337671,0.00005220399,0.0000202761,0.00002965376,0.0002842132,0.00004624677,0.0007804293],"genre_scores_gemma":[0.9967226,0.0005566917,0.0009728431,0.00004529725,0.000009446119,0.00005075258,0.0004465535,0.000005433852,0.001190289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001478456,"threshold_uncertainty_score":0.004945934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007728907291224257,"score_gpt":0.2277487436466441,"score_spread":0.2200198363554199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}