{"id":"W2155830587","doi":"10.1111/j.1365-313x.2012.05084.x","title":"Systematic silencing of benzylisoquinoline alkaloid biosynthetic genes reveals the major route to papaverine in opium poppy","year":2012,"lang":"en","type":"article","venue":"The Plant Journal","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Benzylisoquinoline; Papaverine; Opium Poppy; Sanguinarine; Papaver; Alkaloid; Poppy; Biosynthesis; Biology; Chemistry; Biochemistry; Gene; Stereochemistry; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003010875,0.0001684872,0.0005288079,0.0002126775,0.0001448884,0.00003388752,0.0003785556,0.0000530742,0.0001629068],"category_scores_gemma":[0.000392183,0.00007761257,0.0001265613,0.0003454906,0.00005842064,0.00009354644,0.0001365252,0.0005095284,0.00006655539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008278721,"about_ca_system_score_gemma":0.00008006726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001760149,"about_ca_topic_score_gemma":0.00007343098,"domain_scores_codex":[0.9976829,0.0003458686,0.0007162516,0.0001111365,0.0005765685,0.0005672678],"domain_scores_gemma":[0.9985827,0.0004492719,0.0002063275,0.0004168588,0.0001016471,0.0002432168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001049155,0.00069687,0.04571452,0.009988783,0.0008137196,0.0003072371,0.0108216,0.0001596068,0.9216663,0.001006402,0.004912376,0.002863431],"study_design_scores_gemma":[0.0130518,0.004113461,0.274942,0.09718731,0.003092995,0.09350027,0.03182221,0.004404516,0.4654769,0.001506144,0.008571376,0.002331019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885561,0.004494349,0.00007868453,0.005402409,0.0002268944,0.0007092392,0.00003840933,0.00001044206,0.0004834109],"genre_scores_gemma":[0.9975587,0.0005165868,0.0002212752,0.0003554218,0.000645294,0.00002098739,0.00000449827,0.00002219413,0.000655048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4561894,"threshold_uncertainty_score":0.3164949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03564061658006103,"score_gpt":0.2938407626359347,"score_spread":0.2582001460558737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}