{"id":"W2155856207","doi":"10.1371/journal.pgen.1004474","title":"Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin","year":2014,"lang":"en","type":"review","venue":"PLoS Genetics","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":161,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of British Columbia","funders":"National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute on Aging; Biocenter, University of Oulu; Canadian Institutes of Health Research; Novo Nordisk Fonden; Uppsala Universitet; Oulun Yliopisto; Medical Research Council; Signe ja Ane Gyllenbergin Säätiö; Hjärt-Lungfonden; Novo Nordisk; Juho Vainion Säätiö; National Health and Medical Research Council; Emil Aaltosen Säätiö; Vetenskapsrådet; Ministero della Salute; University of Bristol; Nierstichting; Stiftelsen för Strategisk Forskning; Akademiska Sjukhuset; Academy of Finland; Women and Infants Research Foundation; Raine Medical Research Foundation; Curtin University of Technology; Helsingin Yliopisto; European Commission; Bristol-Myers Squibb; Royal Society; Scottish Government; British Heart Foundation; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; European Science Foundation","keywords":"Transcortin; Biology; Genome-wide association study; Heritability; Genetics; Single-nucleotide polymorphism; Genetic variation; Locus (genetics); Quantitative trait locus; Endocrinology; Internal medicine; Globulin; Gene; Genotype; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007818736,0.000707404,0.0006281649,0.0007556331,0.0004209182,0.0008192772,0.0004457968,0.0006912065,0.002475358],"category_scores_gemma":[0.002488122,0.0002582572,0.001012086,0.001248551,0.0003922943,0.0001379641,0.0004562405,0.0007875827,0.0002514731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000219624,"about_ca_system_score_gemma":0.0002374459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006316594,"about_ca_topic_score_gemma":0.005019438,"domain_scores_codex":[0.9991764,0.0001850598,0.00006009365,0.0003768836,0.0001100636,0.00009136364],"domain_scores_gemma":[0.9988711,0.000468898,0.000307378,0.0001125883,0.00009496724,0.000144947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004695372,0.0001391645,0.9314482,0.0002898801,0.004324662,0.004298755,0.0003609696,0.001536381,0.02758286,0.0003749914,0.001735832,0.02321297],"study_design_scores_gemma":[0.000101146,0.0001230247,0.9933176,0.00002856815,0.000958361,0.001982944,0.0000727155,0.001315525,0.0009354395,0.0002762316,0.0008723239,0.00001618552],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9953784,0.00176488,0.0008601987,0.0001849352,0.00004122474,0.00001375917,0.00109651,0.00005104405,0.0006092419],"genre_scores_gemma":[0.9981822,0.0004139283,0.0005727894,0.0000642864,0.00002746878,0.000006625541,0.0004636644,0.00001305237,0.000256071],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.006316594,"threshold_uncertainty_score":0.01255965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04141546626372643,"score_gpt":0.2943577905966662,"score_spread":0.2529423243329397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}