{"id":"W2155856207","doi":"10.1371/journal.pgen.1004474","title":"Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin","year":2014,"lang":"en","type":"review","venue":"PLoS Genetics","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":161,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of British Columbia","funders":"National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute on Aging; Biocenter, University of Oulu; Canadian Institutes of Health Research; Novo Nordisk Fonden; Uppsala Universitet; Oulun Yliopisto; Medical Research Council; Signe ja Ane Gyllenbergin Säätiö; Hjärt-Lungfonden; Novo Nordisk; Juho Vainion Säätiö; National Health and Medical Research Council; Emil Aaltosen Säätiö; Vetenskapsrådet; Ministero della Salute; University of Bristol; Nierstichting; Stiftelsen för Strategisk Forskning; Akademiska Sjukhuset; Academy of Finland; Women and Infants Research Foundation; Raine Medical Research Foundation; Curtin University of Technology; Helsingin Yliopisto; European Commission; Bristol-Myers Squibb; Royal Society; Scottish Government; British Heart Foundation; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; European Science Foundation","keywords":"Transcortin; Biology; Genome-wide association study; Heritability; Genetics; Single-nucleotide polymorphism; Genetic variation; Locus (genetics); Quantitative trait locus; Endocrinology; Internal medicine; Globulin; Gene; Genotype; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003767236,0.0004236275,0.001574478,0.0001672589,0.0003252374,0.0001305186,0.0001792427,0.0004791384,0.00005662906],"category_scores_gemma":[0.0005700788,0.0003143438,0.0002249855,0.0002460041,0.00007765986,0.00005116281,0.0002865682,0.0004526325,0.0003331367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006931173,"about_ca_system_score_gemma":0.0001747922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007147651,"about_ca_topic_score_gemma":0.00008347681,"domain_scores_codex":[0.9971994,0.0002412568,0.0009622998,0.0004649883,0.0007248873,0.0004072294],"domain_scores_gemma":[0.9974945,0.0006524321,0.0008887734,0.0005395709,0.0002191833,0.0002055629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002841281,0.0004116098,0.02638756,0.03768507,0.00377931,0.000411652,0.001049427,0.00006985361,0.01175193,0.00002291747,0.002166547,0.91598],"study_design_scores_gemma":[0.0012724,0.0006429454,0.01603664,0.01132867,0.00758883,0.000552735,0.00006379349,0.001958849,0.0003589933,0.00003162719,0.9593259,0.0008385906],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.242341,0.7559638,0.000007805558,0.0002380455,0.0001972693,0.00101456,0.0000338574,0.00004778325,0.0001558609],"genre_scores_gemma":[0.01558641,0.9818195,0.00005281006,0.0003282471,0.0002648666,0.00003834082,0.0002382088,0.00009196188,0.001579658],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9571594,"threshold_uncertainty_score":0.9999309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04141546626372643,"score_gpt":0.2943577905966662,"score_spread":0.2529423243329397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}